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MetabolomicsCryogenic OrbiSIMS Localizes Semi-Volatile Molecules in Biological Tissues
OrbiSIMS is a recently developed instrument for label-free imaging of chemicals with micron spatial resolution and high mass resolution. We report a cryogenic workflow for OrbiSIMS (Cryo-OrbiSIMS) that improves chemical detection of lipids and other biomolecules in tissues. Cryo-OrbiSIMS boosts ioni...
2023-03-15 | MTBLS1873 | MetaboLights
UnknownThe FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.
Not available
S-EPMC7788448 | biostudies-literature
ProteomicsDifferential trafficking and expression of PIR proteins in acute and chronic Plasmodium infections
Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression pattern and localisation remain to be elucidated. Protein subcellul...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-14 | PXD031586 | Pride
Proteomics Mouse Malaria Lc-ms/ms Plasmodium falciparum 
UnknownInsights into human genetic variation and population history from 929 diverse genomes.
Not available
S-EPMC7115999 | biostudies-literature
ProteomicsRibosomal protein deficiency generates proteotoxic stress that is alleviated by TOR inhibition
Ribosomes are multi-component molecular machines that synthesize all the proteins of living cells. Understandably, most genes encoding the protein components of ribosomes are essential. Reduction in gene dosage is often viable but deleterious and associated with human syndromes, collectively known a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-01-14 | PXD023021 | Pride
Eif2 Protein translation Diamond blackfan anemia Ribosomes Autophagy Rps23 Ribosomopathies Protein aggregates Tor Proteotoxic stress Apoptosis P62 Rps26 
UnknownPhase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.
Not available
S-EPMC5321073 | biostudies-literature
TranscriptomicsTranscriptomic and proteomic analyses of seasonal photoperiodism in the pea aphid
Aphid adaptation to harsh winter conditions is illustrated by an alternation of their reproductive mode. Aphids detect photoperiod shortening by sensing the length of the night and switch from viviparous parthenogenesis in spring and summer, to oviparous sexual reproduction in autumn. The photoperio...
ORGANISM(S): Acyrthosiphon pisum 
2010-06-19 | E-GEOD-15776 | biostudies-arrayexpress
ProteomicsIntegrator restraints paraspeckles assembly by promoting the 3’-end processing of the polyadenylated lncRNA NEAT1_1
Alternative 3’-end RNA processing provides an important source of transcriptome diversification, which impacts various biological processes and the etiology of diseases, including cancer. Here, we focused on a transcript isoform switch that leads to the readthrough expression of the long noncoding R...
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD015158 | Pride
Cancer Neat1  alternative 3’-end rna processing Integrator Paraspeckles 
UnknownDetection of SARS-CoV-2 N-antigen in blood during acute COVID-19 provides a sensitive new marker and new testing alternatives.
Not available
S-EPMC7724284 | biostudies-literature
UnknownHow much dystrophin is enough: the physiological consequences of different levels of dystrophin in the mdx mouse.
Not available
S-EPMC4492390 | biostudies-literature
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