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MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
ProteomicsAncient proteins identify various Denisovan remains from Southwest China
Two parietal and one radius fragmentary hominin bones were identified from a systematical morphological prescreening of ~60,000 mammalian bone fragments and subsequent ZooMS analysis at Bianfu Cave in Yunan, Southwest China. Combined with two hominin teeth discovered during the excavation, all the f...
ORGANISM(S): Homo sapiens (Human) 
2026-07-24 | PXD073112 | Pride
Lc ms/ms Archaic human Bone 
ProteomicsThe proteome of Middle Pleistocene Xujiayao and common Denisovan cranial features
Shotgun palaeoproteomic analyses were conducted on hominin bone excavated from Xujiayao in northern China, dating to ~220-160 thousand years ago. A sequential fractionation workflow had identified 2096 amino acid positions within 18 proteins from the two bone samples. Further single amino acid polym...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD063518 | Pride
Lc ms/ms Archaic human Bone Dda 
ProteomicsEnamel proteins from six Homo erectus specimens across China
Homo erectus remains have been found in Africa, Eurasia and Southeast Asia, dating back to 2 million years (Ma), but due to their age and preservation, obtaining informative molecular data from them his been difficult. We successfully extracted ancient enamel proteins from six Middle Pleistocene H. ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-22 | PXD068897 | Pride
ProteomicsThe proteome of the late Middle Pleistocene Harbin individual
Shotgun palaeoproteomic analyses were conducted on two petrous samples (64.3 and 35.1 mg, respectively) of a nearly complete cranium from Harbin, China, dating to at least 146,000 years. Ninety-five endogenous proteins were recovered, representing the best preserved proteome ever obtained from homin...
ORGANISM(S): Homo sapiens (Human) 
2025-06-18 | PXD058447 | Pride
Lc ms/ms Archaic human Bone 
ProteomicsProteomic Analysis Reveal Myometrial Fibrosis of Adenomyosis(Human,adenomyosis,tissue,LC-MSMS)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to analyze adenomyotic and normal myometrial tissues from ten AM patients who underwent hysterectomy with myometrial fibrosis confirmed by Masson staining. This analysis established comprehensive proteomic profiles of adenomyosi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058989 | Pride
Human Adenomyosis Tissue Lc-msms 
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