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ProteomicsMultistep mechanism of G-quadruplex resolution during DNA replication
G-quadruplex (or G4) structures are non-canonical DNA structures that form in guanine-rich sequences and threaten genome stability when not properly resolved. G4 unwinding occurs during S phase via an unknown mechanism. Using Xenopus egg extracts, we define a three-step G4 unwinding mechanism that a...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-02-17 | PXD027623 | Pride
G4 resolution G-quadruplex Helicases Dhx36 G4 Fancj Dna replication 
GenomicsDevelopment and Application of G4-Flame as a Visual Biosensor for G4-DNA
Development and Application of G4-Flame as a Visual Biosensor for G4-DNA
PRJNA1392511 | ENA
ProteomicsProteome-wide Identification of DNA Guanine Quadruplex-binding Proteins
DNA sequences of high guanine (G) content have the potential to fold into G quadruplex (G4) structures. DNA G4 is known to play important roles in various cellular processes including DNA replication, transcriptional regulation, and maintenance of genomic integrity. A more complete understanding abo...
ORGANISM(S): Homo sapiens (Human) 
2021-09-29 | PXD026794 | Pride
G-quadruplex Silac Lc-ms/ms 
GenomicsDevelopment and Application of G4-Flame as a Visual Biosensor for G4-DNA
G4-DNA, a non-canonical tetrahelical nucleic acid structure stabilized by stacked G-quartets via Hoogsteen hydrogen bonding, plays critical roles in genomic regulation and disease pathogenesis. Current methodologies for detecting these structures face limitations in specificity, spatiotemporal resol...
ORGANISM(S): Homo sapiens 
2026-02-20 | GSE314730 | GEO
ProteomicsARID1A recruits non-homologous end joining factors to DNA breaks induced by G4 ligands
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. However, it is challenging to predict how ARID1A loss might impact on responses to cancer therapies because it participates in many different cellular pathways. G quadruplex (G4) binding ligands, such ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-15 | PXD063556 | Pride
G4 ligands Arid1a 
TranscriptomicsGene Expression Profiling of human leukemic B-cells. Two-color Microarray-Based Gene Expression Analysis.
Fresh MEC1 cells (chronic lymphocytic leukemia) (ACC-497, DSMZ) previously untreated and treated in cultures in vitro with glycodendrimers (nanoparticle with maltotriose on the surface). MEC1 cells were centrifuged after incubation with drugs or dendrimers. Agilent’s Low Input Quick Amp Labeling Kit...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68094 | biostudies-arrayexpress
UnknownG4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA.
Not available
S-EPMC3167620 | biostudies-literature
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
TranscriptomicsGlutamine Deprivation Triggers TRIB3-Dependent G4-DNA Resolution to Maintain DNA Repair and Tumor Survival [TRIB3]
Glutamine, the most abundant circulating amino acid, is a central metabolite critical for the survival and growth of many tumor cells. Efforts to exploit this vulnerability have met with limited success, due to the inherent adaptability of tumor cells to withstand nutrient scarcity in the tumor micr...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE307271 | GEO
GenomicsGlutamine Deprivation Triggers TRIB3-Dependent G4-DNA Resolution to Maintain DNA Repair and Tumor Survival [CUT&Tag]
Glutamine, the most abundant circulating amino acid, is a central metabolite critical for the survival and growth of many tumor cells. Efforts to exploit this vulnerability have met with limited success, due to the inherent adaptability of tumor cells to withstand nutrient scarcity in the tumor micr...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE306768 | GEO
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