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MetabolomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
2023-01-31 | MTBLS6337 | MetaboLights
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
MetabolomicsDefective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity in Arabidopsis

Cytokinin (CK) in plants regulates both developmental processes and adaptation to environmental stress. Arabidopsis histidine phosphotransfer ahp2,3,5 and type-B response regulator arr1,10,12 triple mutants are almost completely defective in CK signaling, and the ahp2,3,5

2021-11-25 | MTBLS2532 | MetaboLights
ProteomicsB cell-derived GABA elicits IL-10+ macrophages and limits anti-tumor immunity
Small, soluble metabolites are not only essential intermediates in intracellular biochemical processes, but can also influence neighboring cells when released into the extracellular milieu. Here, we identify the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and s...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-15 | PXD028403 | Pride
Anti-tumor immunity Macrophages Gaba B cells 
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
GenomicsAstrocytic NFIX regulates thalamocortical circuits through GABA and Purinergic Signaling
Astrocytic NFIX regulates thalamocortical circuits through GABA and Purinergic Signaling
PRJNA1334293 | ENA
ProteomicsProteomic identification of GAP-binding proteins in colorectal cancer reveals PPP1CA as a direct target of microbial GABA-mediated metabolic rewiring
This dataset corresponds to the proteomic analysis presented in Figure 6A of the manuscript “Obesity-driven microbial GABA depletion promotes metabolic rewiring and colorectal cancer progression.” We performed Drug Affinity Responsive Target Stability (DARTS) and co-immunoprecipitation proteomics us...
ORGANISM(S): Homo sapiens (Human) 
2026-06-21 | PXD069744 | Pride
Gaba  gap  ppp1ca 
MetabolomicsMulti-level analysis of gut microbiome extracellular vesicles-host interaction reveals a connection to gut-brain axis signaling.

Microbiota-released extracellular vesicles (MEVs) have emerged as a key player in intercellular signaling. However, their involvement in the gut-brain axis has been poorly investigated. In this study, we aimed to investigate the cargo capacity of MEVs for bioactive metabolites and their interacti...

2025-08-12 | MTBLS8494 | MetaboLights
ProteomicsGABA regulates IL-1β production in macrophages
Neurotransmitters have been well-documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is still obscure. Here, we demonstrated that GABA orchestrates macrophage maturation and inflammation. GABA treatment during mac...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD037901 | Pride
Macrophage Succinate Succinylation Fad Gaba 
GenomicsGABA regulates electrical activity and tumor initiation in melanoma
GABA regulates electrical activity and tumor initiation in melanoma
PRJNA992460 | ENA
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