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ProteomicsHypothalamus proteomics from mouse models with obesity and anorexia reveals novel therapeutic targets of appetite regulation
This study examined the proteomic profile of hypothalamus in mouse models of obesity and anorexia
ORGANISM(S): Mus musculus (Mouse) 
2016-03-11 | PXD003475 | Pride
Hypothalamus Lc-ms 
ProteomicsIdentification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy
Association between Crh and autophagy in inflammatory bowel disease
ORGANISM(S): Mus musculus (Mouse) 
2016-03-15 | PXD002886 | Pride
Intestine Crh 
ProteomicsBDNF stimulation of protein synthesis in cortical neurons requires the eIF4E kinase Mnk1
Although the Mnks have been known for >15 years, their roles in the regulation of protein synthesis have remained obscure. Here we explore how BDNF stimulates protein synthesis in cortical neurons. Using a combination of pharmacological and genetic approaches, we show that this effect depends on MEK...
ORGANISM(S): Mus musculus (Mouse) 
2014-11-06 | PXD001074 | Pride
Mnk1 Cortical neurons Boncat Mouse Fmrp Silac Bdnf Obitrap elite Eif4e 
ProteomicsQuantitative Proteomic Profiles of Chronic Lymphocytic Leukaemia
Chronic lymphocytic leukaemia (CLL) is a common, adult B-cell leukaemia that has challenges in prognosis and treatment. It is characterised by a heterogeneous clinical course with multiple distinct phenotypes currently defined genetically or with target-specific monoclonal antibodies...
ORGANISM(S): Homo sapiens (Human) 
2018-01-26 | PXD002004 | Pride
Bridging controls Cancer Cll Tmt Leukaemia Whole cell 
ProteomicsProteomic Discovery and Validation of Diagnostic Plasma Biomarkers for Pulmonary Tuberculosis
Despite more than a century fighting against tuberculosis, the World Health Organisation has estimated that around 1.7 million people died of tuberculosis in 2016 and over a quarter of the world’s population is infected. One of the critical hurdles for stopping tuberculosis transmission is early and...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020212 | Pride
Plasma Tuberculosis Shotgun Hyper-fractionation Wgcna Biomarkers Itraq 
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