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Fusicoccadiene synthase from Phomopsis amygdali (PaFS) catalyzes the first committed step in the biosynthesis of Fusicoccin A, a diterpene glycoside and a a potential therapeutic agent. PaFS contains a C-terminal prenyltransferase domain that generates geranylgeranyl diphosphate (GGPP) and an N-term...
ORGANISM(S): Phomopsis sp. amygdali NY7157a 
2021-07-07 | PXD021007 | Pride
TFIIH is a 10-protein complex that is conserved through out eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). In transcription initiation, TFIIH acts as a structural scaffold, phosphorylates the RNA polymerase II (pol II) C-terminal ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-07 | PXD021211 | Pride
Long non-coding RNAs (lncRNAs) are an increasingly studied group of non-protein coding transcripts with a wide variety of molecular functions gaining attention for their roles in numerous biological processes. Nearly 6,000 lncRNAs have been identified in Arabidopsis thaliana but many have yet to be ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-08-12 | PXD033707 | Pride
The evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1/Asf1 co-chaperone cooperate for replication-independent chromatin assembly. Here we report the molecular architecture of the Hir complex with Asf1/H3/H4 via single-particle cryo-EM and crosslinking mass spectrometry.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-08-22 | PXD040705 | Pride
TFIIH is a 10-protein complex that is conserved throughout eukaryotes. TFIIH has two primary cellular functions: transcription initiation and nucleotide excision repair (NER). NER in eukaryotes begins by recognition of a bulky lesion by the obligate dimer Rad4-Rad23. This is followed closely by the ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-07 | PXD021212 | Pride
Cryo-EM Structures of Respiratory bc1-cbb3 type CIII2CIV Supercomplex and Electronic Communication Between the Complexes
ORGANISM(S): Rhodobacter capsulatus 
2021-03-23 | PXD020038 | Pride
The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that exists in both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity. While...
ORGANISM(S): Dictyostelium Discoideum Ax2 
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