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ProteomicsMolecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model
LC-MS/MS of Prss37 WT and KO mice male reproductive tract. Title: Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Authors: Courtney Sutton1,2, Kaori Nozawa1,2, Katarzyna Kent1,2, Alexander Saltzman3, Mei Leng3, Sureshbabu Na...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-07 | MSV000091662 | MassIVE
ProteomicsMultiple reproductive tract-specific whey acidic protein four-disulfide core genes demonstrate functional requirement for sperm differentiation and function in mice
Our research defines the pivotal roles of the WFDC locus genes in male fertility, particularly in the regulation of sperm development and function. By employing CRISPR/Cas9 mediated gene editing strategy to study this gene family, we provided robust genetic evidence confirming their interconnected f...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-26 | PXD053290 | Pride
Crispr/cas9 Kunitz domain Proteolysis Infertility Wap domain Spermiogenesis 
TranscriptomicsSubstantial interindividual and limited intraindividual genomic diversity among tumors from men with metastatic prostate cancer
Intraindividual tumor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that have metastasized. To determine whether the genomic alterations in a single metastasis provide a reasonable assessment of the major oncogenic drivers of other dispersed metastases in a...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-77930 | biostudies-arrayexpress
UnknownLenalidomide plus prednisone results in durable clinical, histopathologic, and molecular responses in patients with myelofibrosis.
Not available
S-EPMC4879697 | biostudies-literature
UnknownPatient Characteristics and Outcomes in Adolescents and Young Adults (AYA) With Acute Myeloid Leukemia (AML).
Not available
S-EPMC4811701 | biostudies-literature
UnknownA randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome.
Not available
S-EPMC4081352 | biostudies-literature
UnknownMinimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia.
Not available
S-EPMC4826052 | biostudies-literature
UnknownCombination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study.
Not available
S-EPMC4816046 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of Mef2 protein in Drosophila during embryonic development
Genomewide mapping of Drosophila Mef2 protein binding during embryonic development. Five consecutive timepoints (2-4, 4-6, 6-8, 8-10, 10-12 hrs after egg-laying) were assayed in four independent repeats each. Two different antibodies were used to precipitate the Mef2 protein. Additionally the respec...
ORGANISM(S): Drosophila melanogaster 
2006-06-06 | E-TABM-56 | biostudies-arrayexpress
UnknownThe metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Not available
S-EPMC9203277 | biostudies-literature
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