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The mitochondrial CLPXP complex supports the coordination and assembly of mitochondrial and nuclear encoded protein complexes in Arabidopsis thaliana. Protein labeling using iTRAQ reagents and application of optimized ChaFRADIC technology to enrich N-Terminal peptides.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-14 | PXD016263 | Pride
Appropriate neural initiation of the pluripotent stem cells in the early embryos is critical for the development of the central nervous system. This process is regulated by the coordination of extrinsic signals and intrinsic programs. However, how the coordination is achieved to ensure proper neural...
ORGANISM(S): Mus musculus 
Oxidative stress (OS) results from genetic defects or stressful environmental challenges that cause unchecked production of reactive oxygen species (ROS). OS has been implicated in many diseases due to its wide ranging damage to nucleic acids, proteins and lipids. Using Halobacterium salinarum NRC...
ORGANISM(S): Halobacterium salinarum 
Protein homeostasis in eukaryotic organelles and their progenitor prokaryotes is regulated by a series of proteases including the caseinolytic protease (CLPP). CLPP has essential roles in chloroplast biogenesis and maintenance, but the significance of the plant mitochondrial CLPP remains unknown an...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-14 | PXD016746 | Pride
A Multi-Parameter Analysis of Cellular Coordination of Major Transcriptome Regulation Mechanisms
Meiosis produces gametes through a specialised, two-step cell division, which is highly error-prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where sister chromatids separate. Uniquely during meiosis I, siste...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-13 | PXD012627 | Pride
Systematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
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