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ProteomicsCo-IP (AP-MS) of Connexin-43 - Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Co-IP Experiment Bait: Cx43-Flag Cell line: Hela Related Publication: Gap Junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo, Maria Kotini, Elias Barriga, Jonathan Leslie, Marc Gentzel, Verena Rauschenberger, Alexandra Schambony, and Roberto Mayor
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010870 | Pride
Ap-ms Hela Co-ip 
ProteomicsObatoclax rescues FUS-ALS phenotypes in iPSC-derived neurons by inducing autophagy
Disruption of protein homeostasis plays an essential role in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons is to de-repress autophagy by disrupting the inhibitory BECN1/BCL2 complex, which has been sho...
ORGANISM(S): Homo sapiens (Human) 
2023-10-16 | PXD042427 | Pride
Dia Autophagy Ipsc-derived neurons Als Bh3 mimetic Label-free quantitative mass spectrometry Fus 
ProteomicsProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae — Spot Identifications
Hexokinase 2 (Hxk2) of Saccharomyces cerevisiae is a dual function hexokinase, acting as a glycolytic enzyme and being involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose repression is accompanied by phosphorylation of Hxk2 at serine 15, which has been attrib...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-03 | PXD037135 | Pride
Proteomics Hxk2 Glucose signaling Hxk1 Serine/threonine protein kinase Yeast Hexokinase Glucose metabolism Phosphorylation Ymr291w/tda1 
ProteomicsSelective regulation of aspartyl intramembrane protease activity by calnexin
Signal peptide peptidase-like 2c (SPPL2c) is a testis-specific aspartyl intramembrane protease that contributes to male gamete function both by catalytic and non-proteolytic mechanisms. Here, we provide an unbiased characterisation of the in vivo interactome of SPPL2c identifying the ER chaperone ca...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD052965 | Pride
Co-ip Signal peptide peptidase-like 2c Mouse Calnexin Sppl2c Testis 
ProteomicsC11orf94/Frey is a key regulator for male fertility by controlling sperm fusion complex assembly
The sperm fusion complex built around the Izumo1 protein is the key male factor for mediation of gamete fusion. Loss of several complex members leads to male infertility. Here, we provide a detailed characterisation of the C11orf94/Frey protein which acts as central chaperone for assembly of the spe...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD030545 | Pride
Ap-ms Gamete fusion Label-free quantitative co-ip Male infertility Mouse Izumo1 C11orf94/frey Lc-ms/ms 
ProteomicsProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae — Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation
Hexokinase 2 (Hxk2) of Saccharomyces cerevisiae is a dual function hexokinase, acting as a glycolytic enzyme and being involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose repression is accompanied by phosphorylation of Hxk2 at serine 15, which has been attrib...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-06 | PXD030105 | Pride
Yeast In-gel digestion Saccharomyces cerevisiae Hexokinase 2d gel elctrophoresis Lc-ms/ms 
ProteomicsSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Recombination-mediated linking of homologous chromosomes is a unique meiotic feature that enables the halving of chromosomal ploidy in sexual life cycles. Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) that are generated by focal multi-protein clusters that condense...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-23 | PXD042179 | Pride
Biochemical assay Meiotic recombination Iho1-hormad1 Protein phosphorylation Label-free quantitative mass spectrometry Meiosis 
ProteomicsSAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA
Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense. This requires discrimination between structurally highly similar self and nonself nucleic acids to avoid aberrant inflammatory responses as in the autoinflammatory disorder Aicardi-Goutires syndrome (AGS). How...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD035182 | Pride
Innate immunity Human Aicardi-goutires syndrome (ags) Samhd1 
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