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ProteomicsFull geroprotection from brief rapamycin treatment by persistently increased intestinal autophagy
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid the adverse side-effects of clinical dosing regimes. Here we show a profound memory effect of brief rapamycin treatment. Brief, early adult treatment extended lifespan in Drosophila to the same...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-07-18 | PXD020820 | Pride
Autophagy Fly Tmt Lifespan Drosophila Rapamycin 
UnknownAttitudes towards geroprotection: measuring willingness, from lifestyle changes to drug use.
Not available
S-EPMC11573782 | biostudies-literature
UnknownLong-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy.
Not available
S-EPMC10154223 | biostudies-literature
UnknownPotential Role of Polyphenolic Flavonoids as Senotherapeutic Agents in Degenerative Diseases and Geroprotection.
Not available
S-EPMC9470070 | biostudies-literature
ProteomicsUrolithin A rewires inter-organellar communication via calcium signaling to promote mitophagy and longevity
Mitochondrial damage and mitophagy deregulation are hallmark features of aging and age-related pathologies. Urolithin A (UA), a potent mitophagy inducer, is known to confer neuroprotection, maintain muscle integrity, and extend healthspan and lifespan across diverse species. However, the molecular m...
ORGANISM(S): Caenorhabditis elegans 
2025-10-15 | PXD056571 | Pride
Itr-1/insp3r Mitophagy Lysosome Tmco-1/tmco Mcu-1/mcu1 Geroprotection Calcium Mitochondria Emc-3/emc3 Aging Urolithin a Er 
UnknownEast Indian sandalwood (Santalum album L.) oil confers neuroprotection and geroprotection in Caenorhabditis elegans via activating SKN-1/Nrf2 signaling pathway.
Not available
S-EPMC6171454 | biostudies-literature
UnknownSIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer.
Not available
S-EPMC7305295 | biostudies-literature
ProteomicsSpermidine is essential for fasting-mediated autophagy and longevity
Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health 1. The natural polyamine spermidine has been linked to autophagy regulation, geroprotection and reduced incidence of cardiovascular and neurodegenerative diseases across speci...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-04-30 | PXD035909 | Pride
Autophagy Nanolc-ms/ms Spermidin Fasting Yeast Human Lifespan Eif5a hypusination Mouse C.elegans 
UnknownSpermidine is essential for fasting-mediated autophagy and longevity.
Not available
S-EPMC11392816 | biostudies-literature
UnknownBiological ageing with HIV infection: evaluating the geroscience hypothesis.
Not available
S-EPMC9454292 | biostudies-literature
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