Sort   by:  
 Page size 
Myofibrillar myopathy (MFM) in horses is a late onset disease that affects performance and athleticism. It is characterized by myofibrillar disarray and protein aggregation with no known cause. The objective of this study was to elucidate the molecular drivers of MFM in Warmblood (WB) horses by prot...
ORGANISM(S): Equus caballus (Horse) 
2021-09-09 | PXD019187 | Pride
During an episode of acute rhabdomyolysis, a microarray study identified differential expression of calcium-regulatory, mitochondrial and metabolic genes in gluteal muscle of Standardbreds. Whether this represents expression related to acute myodegeneration or a specific molecular signature of susce...
ORGANISM(S): Equus caballus (Horse) 
2023-03-11 | PXD026121 | Pride
Unconditioned thoroughbred geldings were exercised to maximal heart rate or fatigue on an equine high-speed treadmill. Skeletal muscle biopsies were taken from the middle gluteal muscle before, immediately after and four hours after exercise.  Three-condition experiment, Pre exercise (T0), Immediat...
ORGANISM(S): Equus caballus 
Recurrent exertional rhabdomyolysis (RER) develops in 5-10% of Thoroughbred racehorses. High-stress environments, nervous temperament, and diet influence the presentation of RER. RER-susceptibility is associated with alterations in intramuscular Ca2+ regulation with detrimental effects on mitochondr...
ORGANISM(S): Equus caballus (Horse) 
2021-01-07 | PXD020100 | Pride
Single-cell RNA sequencing reveals cellular composition of fibrotic fascia associated with gluteal muscle contracture
The purpose of this study was to compare the gene expression profile of recurent exercise rhabdomyolysis vs control muscles in French Trotter to determine any metabolic or structural disorder. Transcriptome analysis revealed 191 genes significantly modulated in rhabdomyolysis vs control muscles (p<...
ORGANISM(S): Equus caballus 
Sort   by:  
 Page size