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ProteomicsGlycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6-deficient spondylodysplastic Ehlers-Danlos syndrome
The spondylodysplastic type of Ehlers-Danlos syndromes (spEDS) is caused by genetic defects in the B4GALT7 or B3GALT6 genes both deranging the biosynthesis of the glycosaminoglycan linkage region of chondroitin/dermatan sulfate and heparan sulfate proteoglycans. In this study we have analyzed the li...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD033230 | Pride
Liquid chromatography Ehlers-danlos syndrome Tandem mass spectrometry Glycoproteomics Linkeropathies Β3galt6 Glycopeptides Bikunin Glycosaminoglycan linkage region 
ProteomicsIdentification of a chondroitin sulfate linkage region trisaccharide
Here, using LC-MS/MS, we describe for the first time a linkage region trisaccharide comprising [-GlcUA-Gal-Xyl-O-] as an alternative point of entry for glycosaminoglycan (GAG) biosynthesis. The trisaccharide was identified in the proteoglycan bikunin from urine of human healthy donors present as a d...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011855 | Pride
Glycosaminoglycan Lc-ms Chondroitin sulfate Hcd Negative ionisation mode Orbitrap Bikunin 
UnknownIdentification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans.
Not available
S-EPMC3945330 | biostudies-literature
ProteomicsLC-MS/MS analysis of IαI proteoglycopeptides
The inter-alpha-trypsin inhibitor (IαI) complex is a macromolecular arrangement of structurally related heavy chain proteins covalently cross-linked to the chondroitin sulfate (CS) chain of the proteoglycan bikunin. The IαI complex is abundant in plasma and associated with inflammation, kidney disea...
ORGANISM(S): Homo sapiens (Human) 
2015-10-02 | PXD002707 | Pride
Protein ambp Chondroitin sulfate Linkage region Mass spectrometry Heavy chain Proteoglycan 
UnknownGlycosaminoglycan linkage region of urinary bikunin as a potentially useful biomarker for β3GalT6-deficient spondylodysplastic Ehlers-Danlos syndrome.
Not available
S-EPMC9458601 | biostudies-literature
ProteomicsGlycosaminoglycan Domain Mapping of cellular chondroitin/dermatan sulfates
Here we report a simple and versatile approach for domain mapping of complex mixtures of glycosaminoglycans (GAGs), GAGDoMa. The approach is based on orthogonal enzymatic depolymerization of the GAGs, generating internal oligosaccharide, non-reducing end, and linkage region GAG domains, nanoflow rev...
ORGANISM(S): Homo sapiens (Human) 
2020-02-18 | PXD014504 | Pride
Higher-energy collision dissociation Gags Glycosaminoglycans Hcd Orbitrap elite Glycomics Negative ionisation mode Ion-pairing reversed-phase chromatography Dermatan sulfate Chondroitin sulfate 
Unknownb3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region.
Not available
S-EPMC7758351 | biostudies-literature
UnknownA Sulfated Glycosaminoglycan Linkage Region is a Novel Type of Human Natural Killer-1 (HNK-1) Epitope Expressed on Aggrecan in Perineuronal Nets.
Not available
S-EPMC4686076 | biostudies-literature
UnknownDynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development.
Not available
S-EPMC6136507 | biostudies-literature
UnknownEXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.
Not available
S-EPMC3611003 | biostudies-literature
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