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UnknownLong-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.
Not available
S-EPMC6733402 | biostudies-literature
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47085 | biostudies-arrayexpress
TranscriptomicsScl specifies hemogenic endothelium and inhibits cardiogenesis via primed enhancers [expression]
Scl/Tal1 confers hemogenic competence and prevents cardiomyogenesis in embryonic endothelium. Here we show that Scl both directly activates a broad gene regulatory network required for hematopoietic stem/progenitor cell (HS/PC) development, and represses transcriptional regulators required for cardi...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-47084 | biostudies-arrayexpress
ProteomicsIntegrated proteomic, DNA methylation, and targeted Next Generation Sequencing reveals relevant heterogeneity in lower-grade meningioma and a new target in NF2 mutated meningiomas
Meningiomas, the most common primary brain tumours, are classified by the World Health Organization (WHO) into grades 1, 2, and 3. Some grade 1 tumours exhibit increased clinical aggressiveness with the biallelic mutation of Neurofibromatosis 2 (NF2) being the most frequent mutation reported. In our...
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD058651 | Pride
Brain tumour Ngs Proteomics Meningioma 
TranscriptomicsGenome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger
Background: HacA/Xbp1 is a conserved bZIP transcription factor in eukaryotic cells which regulates gene expression in response to various forms of secretion stress and as part of secretory cell differentiation. In the present study, we replaced the endogenous hacA gene of an Aspergillus niger strain...
ORGANISM(S): Aspergillus niger 
2012-08-06 | E-GEOD-39070 | biostudies-arrayexpress
OtherAlterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.
Data from ProteomeXchange, PXD ID: PXD000697. Exiperiment: PP1_Mouse_raw_IgG, file: OR8_121211_NL_DC_PP1_Gel4_B_labelfree2.mzml. Published as part of J Am Coll Cardiol. 2015 Jan 20;65(2):163-73 . From the Abstract: {{i}} Cardiac lysates were coimmunoprecipitated with anti-PP1c antibody followed by ...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320014437 | GPMDB
Resource Reanalysis 
ProteomicsNeuroprotective properties of Mesenchymal Stromal Cell–Derived Extracellular Vesicles in Models of Acute Brain Pathology
Extracellular vesicles (EVs) of multipotent mesenchymal stromal cells (MSCs) in various studies have shown a wide range of cytoprotective effects, including neuroprotective ones. It is important to note that the therapeutic effect of EVs is observed regardless of the tissue from which MSCs were isol...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027581 | Pride
Msc Extracellular vesicles Neuroprotection 
ProteomicsSystemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024012 | Pride
Biomarkers Heart failure with preserved ejection fraction Plasma Hypertrophic cardiomyopathy Lc-ms/ms 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035817 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035758 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
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