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MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
UnknownComparison of EHR-based diagnosis documentation locations to a gold standard for risk stratification in patients with multiple chronic conditions.
Not available
S-EPMC6220706 | biostudies-literature
TranscriptomicsMechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis
Data from clinical studies, cell culture, and animal models implicate the urokinase (uPA)/Plasminogen (Plg) system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/Plg stimulate these diseases are not yet defined. We used genetically modified, atherosc...
ORGANISM(S): Mus musculus 
2011-05-03 | E-GEOD-29028 | biostudies-arrayexpress
TranscriptomicsBlood feeding response of insecticide resistant mosquitoes from Ghana, GAH strain
Anopheles gambiae S form adults were drawn from the GAH laboratory colony that originated from the Ahafo region in Ghana. The GAH colony exhibits extensive insecticide resistance (bendiocarb, DDT, dieldrin, permethrin, deltamethrin). Gene expression was compared between blood-fed and sugar-fed femal...
ORGANISM(S): Anopheles gambiae 
2013-08-30 | E-MTAB-1621 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of Bifidobacterium bifidum SC555 in response to various substrates
The purpose of this project was to determine the whole transcriptome response of Bifidobacterium bifidum SC555 to pooled and individual human milk oligosaccharides (HMO) relative to lactose Bacterial isolates grown on lactose, pooled human milk oligosaccharides (HMO), lacto-N-tetraose (LNT), lacto-N...
ORGANISM(S): Bifidobacterium bifidum 
2015-10-28 | E-GEOD-59053 | biostudies-arrayexpress
ProteomicsSolvent Precipitation SP3 (SP4) enhances recovery for proteomics sample preparation without magnetic beads
Complete, reproducible extraction of protein material is essential for comprehensive and unbiased proteome analyses. A current gold standard is single-pot, solid-phase-enhanced sample preparation (SP3), in which organic solvent and magnetic beads are used to denature and capture protein aggregates, ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Drosophila melanogaster (Fruit fly) 
2022-08-01 | PXD032095 | Pride
Microparticles Proteomics Sample preparation Protein aggregation Contaminant removal Lc−ms/ms Protein precipitation 
ProteomicsLabel-free proteomics to study the effect of IL-9 on MDA-MB-231 and HeLa cells
To study the proteomic profile of HeLa and MDA-MB-231 upon IL-9 stimulation, we treated both the cell-lines with the cytokine for 24 hours. Quantitative label-free proteomic analysis was then performed and abundance ratios were obtained for proteins from cells in IL-9 treated v. untreated conditions...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-03 | MSV000086990 | MassIVE
ProteomicsCharaterising the surfaceome of primary equine chondrocytes
The aim of this study was to characterize the surfaceome of primary equine chondrocytes isolated from healthy joints following exposure to the pro-inflammatory cytokines interleukin-1-beta (IL-1β) and tumour necrosis factor-alpha (TNF-α). We employed combined methodology that we recently developed f...
ORGANISM(S): Equus caballus (Horse) 
2020-07-02 | PXD014773 | Pride
Lc-msms Horse Equine Chondrocyte 
ProteomicsPhosphoproteome analysis of DLC1 in breast cancer
Deleted in Liver Cancer-1 (DLC1), a member of the RhoGAP family of proteins, functions as a tumor suppressor in several cancers including breast cancer. However, its clinical relevance is unclear in breast cancer. In this study, expression of DLC1 was correlated with prognosis using publicly availab...
ORGANISM(S): Homo sapiens (Human) 
2018-10-04 | PXD008220 | Pride
Phosphoproteome Dlc1 Breast cancer 
ProteomicsiTRAQ proteomics of sentinel lymph nodes for the identification of extra cellular matrix protein signatures that can flag metastasis in early breast cancer
Background Breast cancer patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and metastasis to this lymph node is crucial for the staging of cancer and the qu...
ORGANISM(S): Homo sapiens (Human) 
2022-05-01 | PXD027668 | Pride
Itraq proteomics Extracellular matrix proteins Early breast cancer Sentinel lymph node metastasis 
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