Sort   by:  
 Page size 
TranscriptomicsUnderstanding toxicity pathways of gold nanoparticles: RNA expression study on Caco-2 human colon carcinoma cells
A safer design and higher eficacy of nano-gold therapeutic formulations requires examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells of citrate-stabilized Au NP of two different si...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-55349 | biostudies-arrayexpress
TranscriptomicsSTRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
Transcriptome comparison to assess the responses of human monocytic cells (THP-1) to gold-nanoparticles (Au-NPs) of two different diameter sizes (5 or 20 nm) with different surface functional groups, i.e., alkylammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-terminated thi...
ORGANISM(S): Homo sapiens 
2019-06-04 | E-MTAB-7093 | biostudies-arrayexpress
TranscriptomicsInvestigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of gold and silicate nanoparticles
In this study, we investigated the gene expression induced by locally delivered gold and silicate nanoaprticles with the diameter of 20 and 100 nm in the retina. We injected nanoparticles into the vitreous cavity of 5-week-old male C57BL/6 mice. Au20 indicates gold nanoparticles of which diameters w...
ORGANISM(S): Mus musculus 
2013-07-31 | E-GEOD-49371 | biostudies-arrayexpress
ProteomicsProteomics study of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
A proteome comparison was performed to assess the responses of human monocytic cells (THP-1) to gold-nanoparticles (Au-NPs) of two different diameter sizes (5 or 20 nm) with different surface functional groups, i.e., alkylammonium bromide, alkyl sodium carboxylate, or poly(ethylene glycol) (PEG)-ter...
ORGANISM(S): Homo sapiens (Human) 
2019-03-18 | PXD010858 | Pride
Thp-1 monocytes Proteomics Gold-nanoparticles 
TranscriptomicsGlobal genetic impact of surface-modified gold nanoparticles on two model human cell lines
Gold nanoparticles (Au NPs) are uniquely suited for various biomedical applications due to the combination of their optical properties with their easily functionalized surfaces. The Au NP surface can be tailored to improve biocompatibility while also attaching targeting ligands or drugs. However, in...
ORGANISM(S): Homo sapiens 
2014-10-01 | E-GEOD-56432 | biostudies-arrayexpress
ProteomicsNon-labelled proteomics expression analysis of PC-3 cells treated with transferrin conjugated gold nanoparticles
Nanoparticles-based therapeutics are being clinically translated for treating cancer. Meanwhile nanoparticles are increasingly being identified as impacting cell regulation and protein expression. Here, we sought to understand how a model of a relatively inert nanoparticle without any therapeutic ag...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039433 | Pride
Antioxidant Proteomics Tem Reactive oxygen species Nanoparticle Glutathione-thioredoxin 
Genomicsin vivo neurogenesis based electromagnetized gold nanoparticles
in vivo neurogenesis based electromagnetized gold nanoparticles
PRJNA702647 | ENA
TranscriptomicsToxicogenomic responses of C. elegans to gold nanoparticles
We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coat...
ORGANISM(S): Caenorhabditis elegans 
2012-04-15 | E-GEOD-32521 | biostudies-arrayexpress
ProteomicsAptamer-conjugated gold nanoparticles enable selective oligonucleotide delivery into muscle 2 stem cells to promote regeneration of dystrophic muscles
Inefficient targeting of muscle stem cells (MuSCs) represents a major bottleneck of current 27 therapeutic strategies for muscular dystrophies, as it precludes the possibility to promote 28 compensatory regeneration. Here we describe a novel delivery platform, based on gold nanoparticles, 29 that en...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-11 | PXD049295 | Pride
Gold nanoparticles Selex Proteomics Oligonucleotide Duchenne muscular dystrophy Aptamer 
GenomicsSTRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
STRT RNAseq of THP-1 monocytic cells exposed to surface modified-gold nanoparticles
PRJEB28075 | ENA
Sort   by:  
 Page size