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ProteomicsAltered signaling associated with chronic arsenic exposure in human skin keratinocytes
Modulation of signaling pathways upon chronic arsenic exposure remains poorly studied. Here we carried out SILAC-based quantitative phosphoproteomics analysis to dissect the signaling induced upon chronic arsenic exposure in human skin keratinocyte cell line, HaCaT. We identified 4,171 unique phosph...
ORGANISM(S): Homo sapiens (Human) 
2017-08-11 | PXD004868 | Pride
Arsenic Silac Chronic exposure Hacat 
ProteomicsSecretome analysis of oral keratinocytes chronically exposed to shisha
Shisha smoking has been associated with multiple diseases including oral cancer. However, a mechanistic study to investigate alteration of secreted proteins in oral cells due to shisha smoking is lacking. Elucidation of differentially secreted proteins by immortalized human normal oral keratinocyte...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD011130 | Pride
Tmt Okf6/tert1 Oral cancer Secretome Waterpipe Proteomics 
ProteomicsMolecular characterization of esophageal squamous cell carcinoma using quantitative proteomics
Esophageal squamous cell carcinoma (ESCC) is a heterogeneous cancer associated with high mortality rate. In India, it is the 6th most common cause of cancer-related mortality. In this study, we employed high-resolution mass spectrometry-based quantitative proteomics to characterize differential prot...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD036238 | Pride
Quantitative proteomics Cell cycle regulation Syvn1 Esophageal squamous cell carcinoma Er stress 
ProteomicsPIM1 kinase promotes gallbladder cancer cell proliferation via inhibition of proline-rich Akt substrate of 40 kDa (PRAS40)
Gallbladder cancer (GBC) is associated with poor disease prognosis with a survival of less than 5 years in 90% the cases. This has been attributed to late presentation of the disease, lack of early diagnostic markers and limited efficiency of therapeutic interventions. Elucidation of the molecular e...
ORGANISM(S): Homo sapiens (Human) 
2019-01-28 | PXD007946 | Pride
Sgi-1776 Targeted therapy Phosphoproteomics Cell survival Gastrointestinal cancer Pi3k/akt/mtor 
ProteomicsA multi-omic analysis to characterize cigarette smoke induced molecular alterations in esophageal cells
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with high mortality rate. Smoking is one of the established risk factors of ESCC. However, there is limited data on molecular alterations associated with cigarette smoke exposure in esophageal cells. Understanding the effect...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD007799 | Pride
Esophageal cancer Cigarette smoke Dna damage response 
ProteomicsA multi-omic analysis to characterize cigarette smoke induced molecular alterations in esophageal cells: phosphoproteomics
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers with high mortality rate. Smoking is one of the established risk factors of ESCC. However, there is limited data on molecular alterations associated with cigarette smoke exposure in esophageal cells. Understanding the effect...
ORGANISM(S): Homo sapiens (Human) 
2021-09-07 | PXD007814 | Pride
Esophageal cancer Cigarette smoke Dna damage response 
ProteomicsSILAC-based quantitative tyrosine phosphoproteomic profiling identifies alternative therapeutic targets to erlotinib in head and neck squamous cell carcinoma
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resist...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD007769 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative proteomics Egfr-tyrosine kinase inhibitor resistance 
ProteomicsSILAC-based proteomic approach to delineate molecular alterations associated with erlotinib resistance in head and neck squamous cell carcinoma
Although Epidermal growth factor receptor (EGFR) is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted small molecule inhibitors such as erlotinib have shown a modest activity in recurrent or advanced HNSCC. To investigate the acquired ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD007768 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative proteomics Egfr-tyrosine kinase inhibitor resistance 
ProteomicsGenetic aberrations in MAP kinase pathway play an important role in erlotinib resistance in head and neck cancer
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resist...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD007785 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative phosphoproteomics Egfr-tyrosine kinase inhibitor resistance 
ProteomicsChronic exposure to chewing tobacco induces metabolic reprogramming and cancer stem cell-like properties in esophageal epithelial cells
Tobacco in its smoke and smokeless form are major risk factors for ESCC (esophageal squamous cell carcinoma). However, molecular alterations associated with smokeless tobacco exposure are poorly understood. In the Indian subcontinent, tobacco is predominantly consumed in chewing form. An understandi...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013396 | Pride
Cancer stem cells Chewing tobacco Esophageal cancer Metabolic reprogramming 
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