Sort   by:  
 Page size 
ProteomicsIn vivo Brain GPCR Signaling Elucidated by Phosphoproteomics
Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR) as model GPCR, we employed high-throughput phosphoproteomics to investigate downstream signa...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-15 | PXD006637 | Pride
Gpcr brain phosphoproteomics 
ProteomicsHEK293 femtomolar GPCR signaling
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins; they participate in all physiological processes and are the targets of 30% of marketed drugs. Typically, nanomolar-micromolar concentrations of ligand are used to activate GPCRs in experimental systems. How...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD011033 | Pride
Compartmentalized signaling Femtomolar Camp B2ar M3r Signaling complex Gpcr Highly sensitive Ultra-low 
ModelsBush2016 - Simplified Carrousel model of GPCR
Bush2016 - Simplified Carrousel model of GPCR This model is described in the article: Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Bush A, Vasen G, Constantinou A, Dunayevich P, Patop IL, Blaustein M, Colman-Lerner A. Mol. Syst. Biol. 2...
2024-09-02 | BIOMD0000000637 | BioModels
ModelsCroft2013 - GPCR-RGS interaction that compartmentalizes RGS activity
Croft2013 - GPCR-RGS interaction that compartmentalizes RGS activity Through modelling studies, the classic quaternary complex (ligand-GPCR-G-RGS) has been extended to include an additional layer of regulation through GPCR-RGS interactions, which facilitate the compartmentalization...
2024-09-02 | BIOMD0000000479 | BioModels
ModelsBush2016 - Extended Carrousel model of GPCR-RGS
Bush2016 - Extended Carrousel model of GPCR-RGS This model is described in the article: Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Bush A, Vasen G, Constantinou A, Dunayevich P, Patop IL, Blaustein M, Colman-Lerner A. Mol. Syst. Biol....
2024-09-02 | BIOMD0000000638 | BioModels
TranscriptomicsExpression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
This SuperSeries is composed of the following subset Series: GSE25886: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in 3 mouse cell lines: AtT20, BV2 and N18 GSE25894: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in the HEK293 cell line Refer to individu...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-25901 | biostudies-arrayexpress
TranscriptomicsInflammatory mediators alter astrocyte genomic profiles and G-protein receptor evoked calcium signaling
Inflammation features in diverse central nervous system disorders such as stroke, trauma, neurodegeneration, infection and autoimmunity. To better understand how inflammatory mediators may alter astrocyte functions, we examined the effects of transforming growth factor-β1 (TGF-β1), lipopolysacchar...
ORGANISM(S): Mus musculus 
2012-10-18 | E-GEOD-36089 | biostudies-arrayexpress
UnknownLPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration.
Not available
S-EPMC10518940 | biostudies-literature
UnknownMolecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications.
Not available
S-EPMC10461325 | biostudies-literature
UnknownDiscovery of GPCR ligands for probing signal transduction pathways.
Not available
S-EPMC4246677 | biostudies-literature
Sort   by:  
 Page size