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ProteomicsGRK-biased adrenergic agonists for the treatment of type II diabetes and obesity
Biased agonism of G protein-coupled receptors (GPCRs) holds great promise for the development of safer medications. Current efforts have explored the balance between heterotrimeric G proteins and the scaffold protein b-arrestin; however, other transducers like GPCR kinases (GRKs) represent important...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-05 | PXD058545 | Pride
B2ar Phosphoproteomics Obesity Grk2 Diabetes 
TranscriptomicsAcute effects of beta2-adrenergic receptor activation on macrophage transcriptome
The study was designed to investigate the acute effects of B2AR receptor activation on global gene expression changes in bone marrow-derived macrophages. Fenoterol was chosen as B2AR agonist, but our earlier experiments using B2AR antagonists and B2AR knockout cells indicated that norepinephrine sig...
ORGANISM(S): Mus musculus 
2020-11-03 | GSE160640 | GEO
UnknownBeta 2 adrenergic receptor and mu opioid receptor interact to potentiate the aggressiveness of human breast cancer cell by activating the glycogen synthase kinase 3 signaling.
Not available
S-EPMC9107672 | biostudies-literature
UnknownSrc regulates sequence-dependent beta-2 adrenergic receptor recycling via cortactin phosphorylation.
Not available
S-EPMC4205176 | biostudies-literature
UnknownReprogramming of G protein-coupled receptor recycling and signaling by a kinase switch.
Not available
S-EPMC3780909 | biostudies-literature
UnknownBeta 2-Adrenergic Receptor in Circulating Cancer-Associated Cells Predicts for Increases in Stromal Macrophages in Circulation and Patient Survival in Metastatic Breast Cancer.
Not available
S-EPMC9266803 | biostudies-literature
UnknownLoss of bronchoprotection with ICS plus LABA treatment, β-receptor dynamics, and the effect of alendronate.
Not available
S-EPMC6950766 | biostudies-literature
UnknownDistinct G protein-coupled receptor recycling pathways allow spatial control of downstream G protein signaling.
Not available
S-EPMC5037407 | biostudies-literature
GenomicsAcute effects of beta2-adrenergic receptor activation on macrophage transcriptome
Acute effects of beta2-adrenergic receptor activation on macrophage transcriptome
PRJNA673830 | ENA
ProteomicsHEK293 femtomolar GPCR signaling
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins; they participate in all physiological processes and are the targets of 30% of marketed drugs. Typically, nanomolar-micromolar concentrations of ligand are used to activate GPCRs in experimental systems. How...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD011033 | Pride
Compartmentalized signaling Femtomolar Camp B2ar M3r Signaling complex Gpcr Highly sensitive Ultra-low 
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