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ProteomicsSubstrate specificity divergence of granzyme tryptases.
Elucidating the true physiological functions of granzymes has been challenging since the origin of the granzyme studied, the use of non-physiological granzyme concentrations and the interspecies use of granzymes, with extrapolation of all these data to orthologous granzymes has led to inconsistencie...
ORGANISM(S): Homo sapiens (Human) 
2015-09-30 | PXD000570 | Pride
Proteomics Granzyme N-terminal cofradic Protease Specificity profile 
ProteomicsConservation of the extended substrate specificity profiles among homologous granzymes across species
Granzymes are a family of structurally related serine proteases involved in immunity. To date four out of five human granzymes have been assigned orthologues in mice; however for granzyme H, no clear murine orthologue has been suggested and its role in cytotoxicity remains controversial. In this stu...
ORGANISM(S): Mus musculus (Mouse) 
2013-11-27 | PXD000152 | Pride
Lc-msms N-terminal cofradic Granzyme h Granzyme c Human Mouse 
ProteomicsHuman Differentiated SH-SY5Y neuroblastoma cells treated with Granzyme K
Human Differentiated SH-SY5Y neuroblastoma cells treated with 150 nM GrK alone or together with 100 nM SCH79797 PAR-1 inhibitor to evaluate the impact of granzyme K (GrK) on neuronal functions.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD064640 | Pride
Neuroblastoma Alzheimer's disease Granzyme k Sh-sy5y 
UnknownIdentification and annotation of bovine granzyme genes reveals a novel granzyme encoded within the trypsin-like locus.
Not available
S-EPMC6096847 | biostudies-literature
TranscriptomicsHeLa cell response to overexpression of wild type and mutated forms of the P19 splice variant of c-H-ras
The c-H-ras proto-oncogene undergoes alternative splicing of the exon termed IDX giving rise to a novel protein of the Ras family, p19 (H-RasIDX). The experiment tests the effect on the transcriptome of overexpressing the wild type and W164A mutated forms of p19. Keywords: genetic modification Thre...
ORGANISM(S): Homo sapiens 
2009-12-29 | E-GEOD-12059 | biostudies-arrayexpress
GenomicsGranzyme B-mimicking nanozyme-containing nanovesicles for tumour-targeting delivery
Granzyme B-mimicking nanozyme-containing nanovesicles for tumour-targeting delivery
PRJNA1377629 | ENA
UnknownWidespread and dynamic expression of granzyme C by skin-resident antiviral T cells.
Not available
S-EPMC10552530 | biostudies-literature
UnknownNon-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity.
Not available
S-EPMC6452901 | biostudies-literature
UnknownGranzyme B inhibition reduces disease severity in autoimmune blistering diseases.
Not available
S-EPMC7804321 | biostudies-literature
GenomicsGranzyme B links CFH Genetic Risk to Vitronectin Loss in Macular Degeneration
Granzyme B links CFH Genetic Risk to Vitronectin Loss in Macular Degeneration
PRJNA1430216 | ENA
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