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ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
ProteomicsProteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates
Cancer metastasis causes approximately 90% of all cancer-related death. Independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis progresses by cancer cell migration and invasion throughout the body. This migration of cancer cells ...
ORGANISM(S): Homo sapiens (Human) 
2018-04-12 | PXD004658 | Pride
Breast cancer  metastasis  migration  pseudopodia  proteomics 
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo sapiens (Human) 
2016-02-09 | PXD001856 | Pride
Rna sequencing Bone marrow Human mesenchymal stem cells Human embryonic stem cells Quantitative proteomics Aptamer-based somsscan assay Lc-ms/ms 
ProteomicsA Systems-Level Characterization of the Differentiation of Human Embryonic Stem Cells into Mesenchymal Stem Cells
Mesenchymal stem/stromal cells (MSCs) are self-renewing multipotent cells with regenerative, secretory and immunomodulatory capabilities that are beneficial for the treatment of various diseases. To avoid the issues that come with using tissue-derived MSCs in therapy, MSCs may be generated by the di...
ORGANISM(S): Homo sapiens (Human) 
2019-07-23 | PXD004652 | Pride
Human embryonic stem cells Transcriptome Bone marrow Phosphoproteome Differentiation Human mesenchymal stem cells Quantitative proteomics Proteome Lc-ms/ms Rna-seq 
ProteomicsGenome-wide identification and functional analysis of Apobec-1 mediated C-to-U RNA editing in mouse small intestine and liver
Background: RNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of base modification, whose prototype is inte...
ORGANISM(S): Mus musculus (Mouse) 
2014-06-02 | PXD001007 | Pride
Intestine Rna editing Polysomes Liver 
ProteomicsAdaptation of a commonly used, chemically defined medium for human embryonic stem cells to stable isotope labeling with amino acids in cell culture (SILAC)
Metabolic labeling with stable isotopes is a prominent technique for comparative quantitative proteomics and stable isotope labeling with amino acids in cell culture (SILAC) is the most commonly used approach. SILAC is, however, traditionally limited to simple tissue culture regiments and only rare...
ORGANISM(S): Homo sapiens (Human) 
2013-06-17 | PXD000151 | Pride
Stable isotope labeling by amino acids in cell culture Silac Human embryonic stem cells Hesc 
ProteomicsComprehensive transcriptomic and proteomic characterization of human mesenchymal stem cells reveals source specific cellular markers
Mesenchymal stem cells (MSC) are multipotent cells with great potential in therapy, reflected by more than 500 MSC-based clinical trials registered with the NIH. MSC are derived from multiple tissues but require invasive harvesting and imply donor-to-donor variability. Embryonic stem cell-derived MS...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080827 | MassIVE
ProteomicsA PhotoClick cholesterol-based quantitative proteomics screen for cytoplasmic sterol binding proteins in Saccharomyces cerevisiae
Ergosterol is a prominent component of the yeast plasma membrane and essential for yeast cell viability. It is synthesized in the endoplasmic reticulum and transported to the plasma membrane by non-vesicular mechanisms requiring carrier proteins. Oxysterol binding protein homologues and yeast StARki...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-25 | PXD014555 | Pride
Lc-ms2 Chemical biology Sterol 
ProteomicsThe intercellular signaling network of ovarian cancer metastases
Background: Transcoelomic spread is the major route of metastasis of ovarian high-grade serous carcinoma (HGSC) with the omentum as the major metastatic site. Its unique tumor microenvironment with its large populations of adipocytes, mesothelial cells and immune cells establishes an intercellular s...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD028248 | Pride
Mesothelial cell Adipocyte Hsp70 Ovarian carcinoma Omentum Carcinoma-associated fibroblast Wnt4 Tumor microenvironment Signaling network Metastasis 
ProteomicsMechanical forces regulate cardiomyocyte myofilament maturation via the VCL-SSH1-CFL axis
Mechanical forces regulate cell behavior and tissue morphogenesis. In particular, cardiac tissues require mechanical stimuli generated by the heartbeat for differentiation and maturation, but the molecular mechanisms underlying these processes remain unclear. Here, we first show that mechanical fo...
ORGANISM(S): Rattus norvegicus (Rat) 
2019-09-06 | PXD014624 | Pride
Heart Rattus norvegicus Cardiac contractility 
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