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ProteomicsBottom-up mapping of RSV nonstructural protein 1 (NS1) for HDX-MS data analysis
LC-MS/MS analysis of pepsin-digested RSV-NS1 protein to identify peptides for HDX-MS data processing
ORGANISM(S): Respiratory syncytial virus 
2025-05-07 | PXD054004 | Pride
Ns1 Rsv Hdx-ms 
ProteomicsRSV nonstructural protein 1 (NS1) HDX LC-MS data
Raw liquid chromatography-mass spectrometry (LC-MS) datafiles acquired for hydrogen-deuterium exchange (HDX) of RSV nonstructural protein 1 (NS1)
ORGANISM(S): Human Respiratory syncytial virus 9320 
2025-05-07 | PXD054005 | Pride
Rsv ns1 hdx-ms 
ProteomicsNanoparticles and photochemistry for Native-like transmembrane protein footprinting
Mass spectrometry based footprinting can probe higher order structure of proteins. We bond photocatalytic nanoparticles to a lipid bilayer that, upon laser irradiation, produce high local concentrations of radicals that penetrate the lipid layer made permeable by a simultaneous laser-initiated PB re...
ORGANISM(S): Homo sapiens (Human) 
2021-09-26 | PXD027819 | Pride
Footprinting Membrane protein 
ProteomicsFast Fluoroalkylation of Proteins Uncovers Structure and Dynamics of Biological Macromolecules
Stable covalent labeling of proteins in combination with mass spectrometry has been established as a complementary technique to classical structural methods, such as X Ray, NMR, or Cryo-EM used for protein structure determination. Although the current stable covalent labeling techniques enable to mo...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD027310 | Pride
Radical labeling Mass spectrometry Protein footprinting Conformational changes Fluoroalkylation Hyperva-lent iodine reagents Protein structure Togni reagents Protein fingerprinting Epitope mapping Protein surface mapping Radicals Proteomics Interactomics Trifluoromethylation 
ProteomicsIn-cell isotope-coded labeling and LC-MS/MS analysis probe warfarin inhibition mechanism
Warfarin targets human vitamin K epoxide reductase (hVKOR), a redox enzyme in the membrane of endoplasmic reticulum (ER), to prevent the formation of blood clots. Although warfarin has been a popular medication since 1954, its mechanism of action is still unclear. A fundamental issue is the controve...
ORGANISM(S): Homo sapiens (Human) 
2017-03-30 | PXD003774 | Pride
Human vitamin k epoxide reuctase N-ethylmeleimide Isotope Bottom-up proteomics Warfarin 
TranscriptomicsAnalysis of ethanologenic E.coli strain GLBRCE1 during fermentation of alkaline-pretreated corn stover hydrolysate
The physiology of ethanologenic Escherichia coli grown anaerobically in alkaline-pretreated plant hydrolysates is not well studied. To gain insight into how E. coli responds to such hydrolysates, we studied an E. coli K-12 ethanologen fermenting a hydrolysate prepared from corn stover pre-treated by...
ORGANISM(S): Escherichia coli 
2012-06-17 | E-GEOD-35049 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pig induced pluripotent stem cells from somatic cells
We have derived induced porcine pluripotent stem cells (iPPSCs) from porcine fetal fibroblasts by lentiviral transduction of four human (h) reprogramming genes, hOCT4, hSOX2, hKLF4 and hc-MYC , the same combination of factors used for deriving induced pluripotent stem cell (iPSC) lines in both mous...
ORGANISM(S): Sus scrofa 
2009-07-19 | E-GEOD-15472 | biostudies-arrayexpress
TranscriptomicsTranscriptional regulation of human pterygial-derived fibroblasts in response to FCS and TGFbeta
Pterygium is an ocular disease that involves a fleshy growth from the conjunctiva across the cornea. It demonstrates accelerated fibroblastic proliferation, matrix deposition and neovascularisation, which is closely linked to inflammation. Growth factor levels are elevated in human pterygium through...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4871 | biostudies-arrayexpress
Transcriptomicscgh_colvsc24_wg-Analysis of epigenomic changes in hybrids Arabidopsis thaliana Col-0, C24 and Cvi accessions
a2e_heterosis - cgh_colvsc24_wg - Arabidopsis thaliana accessions (Col-0, C24 and Cvi) and their hybrid were used to investigate the dynamics of the epigenome after intraspecific hybridization between - Comparative genome hybridization between Arabidopsis thaliana accessions Col-0 and C24. cgh; tech...
ORGANISM(S): Arabidopsis thaliana 
2011-05-17 | E-GEOD-24831 | biostudies-arrayexpress
Transcriptomicscgh_colvscvi_wg-Analysis of epigenomic changes in hybrids Arabidopsis thaliana Col-0, C24 and Cvi accessions
a2e_heterosis - cgh_colvscvi_wg - Arabidopsis thaliana accessions (Col-0, C24 and Cvi) and their hybrid were used to investigate the dynamics of the epigenome after intraspecific hybridization between - Comparative genome hybridization between Arabidopsis thaliana accessions Col-0 and CVi. 2 dye-swa...
ORGANISM(S): Arabidopsis thaliana 
2011-05-17 | E-GEOD-24835 | biostudies-arrayexpress
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