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ProteomicsGcn4-dependent translation reduction in long-lived ribosomal protein deletion strains
Deletion of several ribosomal proteins genes (RPKOs) has been shown to extend the lifespan of Saccharomyces cerevisiae in a Gcn4-dependent manner. To characterize the underlying mechanisms, we systematically analyzed the gene expression of both short- and long-lived RPKO strains at multiple levels. ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-07-06 | PXD004760 | Pride
Tmt Gnc4 Yeast Aging 
ProteomicsNK cell-derived GM-CSF is critical for enhancing pathological arthritis
GM-CSF is involved in immune complex (IC)-mediated arthritis. However, little is known about what is the cellular source of GM-CSF and how it is regulated during IC-mediated inflammation. Using novel GM-CSF reporter mice, we show that NK cells produce GM-CSF during an IC-mediated model of inflammato...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-19 | PXD012794 | Pride
Nk cells Arthritis Neutrophils Gm-csf 
ProteomicsAGO1x stop codon readthrough isoform
Translational readthrough (TR), the elongation of the polypeptide chain by the ribosome beyond the stop codon, was initially observed for viral RNA and more recently reported for yeast and animal transcripts. TR modulates the protein output and diversifies the proteome 1–5. Here, we report that the ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD009401 | Pride
Lc-ms Ago1 Prm 
ProteomicsAnalysis of sectreted proteins from breast cancer cells
Analysis of sectreted proteins from pure media, LX and Heps breast cancer cells grown in conditioned media. All samples were prepared in biological triplicates.
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD015426 | Pride
Lc-ms Secretome Conditioned media 
ProteomicsA rare-codon-based translational program of cell proliferation
The codon usage of mRNAs controls the speed of translation elongation, which is primarily determined by the abundance of cognate tRNAs. By profiling mRNA expression around the cell cycle we found that mRNAs that are relatively upregulate in the G2/M phase are enriched in rare codons. To understand ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-21 | PXD016034 | Pride
Cell proliferation Codon usage Translation elongation Rare codons Lfq Trna pools Translation control 
UnknownReporting Clinical End Points and Safety Events in an Acute Coronary Syndrome Trial: Results With Integrated Collection.
Not available
S-EPMC5533035 | biostudies-literature
UnknownEvaluation of Automatic Blood Analyzer as Screening Method in Fetomaternal Hemorrhage.
Not available
S-EPMC6413365 | biostudies-literature
UnknownPrefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis.
Not available
S-EPMC10754178 | biostudies-literature
UnknownBiomolecular insights into North African-related ancestry, mobility and diet in eleventh-century Al-Andalus.
Not available
S-EPMC8438022 | biostudies-literature
UnknownOvarian Cancer-Associated Ascites Have High Proportions of Cytokine-Responsive CD56bright NK Cells.
Not available
S-EPMC8306021 | biostudies-literature
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