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ProteomicsQuantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells
To explore reovirus-macrophage interactions, we performed tandem mass tag (TMT)-based quantitative temporal proteomics on mouse bone marrow-derived macrophages (BMMs) generated with 2 cytokines, M-CSF and GM-CSF, representing anti- and pro-inflammatory macrophages, respectively. We quantified 6,863 ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD015203 | Pride
Reovirus Cell differentiation Macrophages Oncolytic viruses Antigen presentation/processing Viral defense Quantitative proteomics Anti-viral immune response 
ProteomicsNAD Salvage Supports Serine Biosynthesis
Maintenance of NAD+ levels by mitochondrial complex I, the NAD+ salvage pathway, and other routes is an important factor in of neurodegenerative disease and cancer. Both the production of NAD+ and the metabolic enzymes that require it as a redox cofactor or substrate differ widely in abundance acros...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD007790 | Pride
Serine Complex i Fk866 Nad 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-05 | PXD011444 | Pride
Source proteins Mhc-i peptides 
ProteomicsCell Surface Expression with FK866
Maintenance of NAD+ levels by mitochondrial complex I, the NAD+ salvage pathway, and other routes is an important factor in of neurodegenerative disease and cancer. Both the production of NAD+ and the metabolic enzymes that require it as a redox cofactor or substrate differ widely in abundance acros...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD007791 | Pride
Cell surface Ttmt Fk866 
ProteomicsIntegrative MHC-I peptidome quantitation with isobaric tagging mass spectrometry
Despite the appreciation of CD8+ T cell anti-tumor immune responses towards improvement patient outcomes, the MHC-I peptides that facilitate the response are poorly described. Alternatively, whether cancer therapies alter the MHC-I peptide repertoire has not been fully assessed due to the lack of qu...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD011464 | Pride
Mhc-i peptidomics Source proteome 
ProteomicsMapping of immunopeptidome of cancer immunotherapy with oncolytic virus and checkpoint blockade
The elucidation of therapy-induced changes to the class I major histocompatibility complex (MHC-I)-bound tumor antigens is crucial for understanding immune-mediated tumor eradication and identifying potential targets for peptide vaccines to enhance the efficacy of immunotherapies. Here, we investiga...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-06 | PXD024369 | Pride
Antitumor immunity Mhc immunoprecipitation Immune checkpoint blockade Oncolytic virus Lc-sps-ms3 Murine Fibrosarcoma Lc-ms/ms 
ProteomicsReshaping of the MHC-I ligandome in response to reovirus-based cancer immunotherapy
Oncolytic viruses (OVs), known for their cancer-killing characteristics, overturn tumor-associated defects in antigen presentation through the MHC class I pathway and induce protective neo antitumor CD8 T cell responses. Nonetheless, whether OVs shape the tumor MHC-I ligandome remains unknown. Here,...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-20 | PXD013066 | Pride
Antitumor immunity Reovirus Mhc ligandome Mass spectrometry Cancer immunotherapy Cd8 t cell epitopes Oncolytic virus 
ProteomicsQuantitative Temporal in vivo Proteomics (QTiPs) deciphers the transition of inflammatory CD11b+,Ly6G-,Ly6Chigh myeloid cells into M2-like macrophages
Phenotypic transition of myeloid cells into distinct lineages in vivo is important in pathogen response. To monitor immune cell phenotype transitions in vivo, we developed a quantitative temporal in vivo proteomics (QTiPs) platform, performing multiplexed (10-plex) tandem-mass-tag (TMT)-based mass s...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD005064 | Pride
Proteomics Myeloid cells M2-like macrophages Infection 
ProteomicsAfter virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is know...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-30 | PXD039614 | Pride
T cell Mouse Reovirus 
ProteomicsTumor suppressor TAp73 is required to maintain pluripotency of cancer stem cells
Cancer stem cells (CSCs) are resistant to conventional chemotherapy and are hence responsible for cancer relapse. Pluripotency is a characteristic of CSCs which allows them to rapidly proliferate while maintaining the ability to differentiate into various lineages. We found that TAp73, but not its h...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD005407 | Pride
Stem cells P73 
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