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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsTranscription profiling of primary human CD4+T-cells overexpressing TET1 polarized towards Th1
Differentiation of CD4+T-cells into effector subsets is a critical component of the adaptive immune system and an incorrect response can lead to autoimmunity or immune deficiency. Cellular differentiation including T-cell differentiation is accompanied by large-scale epigenetic remodeling, including...
ORGANISM(S): Homo sapiens 
2016-07-11 | E-MTAB-4685 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Bone Marrow Macrophages and Spleenic Macrophages Transcriptomes in mouse T cell acute lymphoblastic leukemia
The goals of this study aim to reveal functional and phenotypic diversity of leukemia-associated macrophages in response to the microenvironmental cues in mouse T cell acute lymphoblastic leukemia Compare Transcriptomes of macrophages in T cell acute leukemia which are suggested as leukemia-associat...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-63751 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients.
Single-cell RNA sequencing on 5063 single T cells isolated from peripheral blood, tumour and adjacent normal tissues from six hepatocellular carcinoma patients. The transcriptional properties of these individual cells, coupled with the assembled T cell receptor (TCR) sequences, were used to delineat...
EGAS00001002072 | EGA
TranscriptomicsSuppression of T Cell Activation and Collagen Accumulation by an Anti-IFNAR1 mAb, Anifrolumab, in Adult Patients with Systemic Sclerosis
Type I IFNs are implicated in the pathophysiology of systemic sclerosis (SSc). Recently, a Phase I open-label trial was conducted with an anti-IFNAR1 receptor antibody (anifrolumab) in adult SSc patients. In this study, we aim to assess the downstream effects of anifrolumab and elucidate the role of...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-65336 | biostudies-arrayexpress
Transcriptomicsscreen differential expressed microRNAs of RA patients
We screened the differential expressed microRNA from the rheumatoid arthritis patients and healthy person in their hydrops articuli CD4+ T cells. We screened the differential expressed microRNA from the rheumatoid arthritis patients and healthy person in their hydrops articuli CD4+ T cells. 1.Isolat...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-21118 | biostudies-arrayexpress
ProteomicsIP-MS of DCAF1/VprBP interacting proteins in mouse CD4 T cells
DCAF1, also known as VprBP (HIV-1-viral-protein-r-binding-protein), is an evolutionary conserved substrate-binding subunit of CRL4 (Cul4a-Ddb1-Roc1) ubiquitin ligase complex. It is a cellular protein targeted by HIV-1 viral protein R (Vpr). DCAF1 modulates cellular response against HIV in macrophage...
ORGANISM(S): Mus musculus (Mouse) 
2016-01-12 | PXD003180 | Pride
Dcaf1 T cell Vprbp Hiv-1 
TranscriptomicsCoexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones...
ORGANISM(S): Homo sapiens 
2013-12-20 | E-GEOD-53514 | biostudies-arrayexpress
TranscriptomicsAlternative Capture of Noncoding RNAs or Protein-Coding Genes by Herpesviruses to Alter Host T-Cell Function
In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in ...
ORGANISM(S): Callithrix jacchus 
2014-09-01 | E-GEOD-55185 | biostudies-arrayexpress
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