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ProteomicsWaddington revisited: Organ transformation by environmental disruption of protein integrity and epigenetic memory in Drosophila
Despite significant progress in the mechanistic understanding of epigenetic reprogramming of cells, the basis of 'organ reprogramming' by (epi-)gene-environment interactions remained largely obscured. Here, we use the ether-induced haltere-to-wing transformations in Drosophila as a model for epigene...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-04-24 | PXD050958 | Pride
Bithorax phenocopy Chaperone response Epigenetic memory Ubx Fly embryos Haltere-to-wing transformation Heat-shock proteins Haltere Diethyl ether Protein-misfolding Trithorax Waddington Ultrabithorax Wing Epigenetics Trx Development Organogenesis Hsp90 H3k27 tri-methylation H3k4 tri-methylation 
UnknownSelector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner.
Not available
S-EPMC5703612 | biostudies-literature
GenomicsA common set of DNA regulatory elements shapes Drosophila appendages
We mapped open chromatin by FAIRE-seq and measured gene expression by RNA-seq in 3 types of Drosophila samples: staged whole embryos, imaginal discs, pharate appendages. We first demonstrate that regions of open chromatin precisely define regions of enhancer activity in developing embryos. In contra...
ORGANISM(S): Drosophila melanogaster 
2013-11-07 | E-GEOD-38727 | biostudies-arrayexpress
TranscriptomicsGenome level identification of direct Ubx targets from third-instar imaginal discs
Hox proteins are transcription factors and key regulators of segmental identity along the anterior posterior axis across all bilateral animals. Despite decades of research, mechanism by which Hox proteins select their targets and specify segmental identity remains elusive. To address this question w...
ORGANISM(S): Drosophila melanogaster 
2011-12-22 | E-GEOD-28778 | biostudies-arrayexpress
TranscriptomicsIdentification of targets of Ultrabithorax
The identity of every segment in the fruitfly Drosophila melanogaster is determined by the action of one or more homeotic selector genes. These genes encode proteins containing DNA-binding domains and function by regulating downstream target genes. The structure and function of homeotic genes are hi...
ORGANISM(S): Drosophila melanogaster 
2010-06-10 | E-GEOD-1412 | biostudies-arrayexpress
UnknownChromatin changes in SMARCAL1 deficiency: A hypothesis for the gene expression alterations of Schimke immuno-osseous dysplasia.
Not available
S-EPMC5215361 | biostudies-literature
TranscriptomicsIdentification of differentially expressed genes in fore and hind wing buds of IV instar larvae of Bombyx mori (Daizo)
Amongst the various different insect groups, there is remarkable diversity in the number and size of wings. However the development of the basic body plan in insects is similar to a large extent. The genes of the hox complex regulate various pathways to bring about the development or modification of...
ORGANISM(S): Bombyx mori 
2016-07-27 | E-GEOD-71988 | biostudies-arrayexpress
GenomicsIdentification of genome wide targets of the hox protein Ultrabithorax (Ubx) in larval wing buds of Bombyx mori (Daizo)
Amongst the various different insect groups, there is remarkable diversity in the number and size of wings. However the development of the basic body plan in insects is similar to a large extent. The genes of the hox complex regulate various pathways to bring about the development or modification of...
ORGANISM(S): Bombyx mori 
2016-07-27 | E-GEOD-71990 | biostudies-arrayexpress
GenomicsThe tumor suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements
In Drosophila, defects in asymmetric cell division can result in the formation of stem cell derived tumors. Here, we reveal a different mechanism that can result in the formation of very similar terminal brain tumor phenotypes. We demonstrate that brain tumors in l(3)mbt mutants originate from overp...
ORGANISM(S): Drosophila melanogaster 
2011-08-29 | E-GEOD-29206 | biostudies-arrayexpress
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