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TranscriptomicsAn epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS
In Drosophila, Polycomb Response Elements (PREs) are identified as genomic sequences allowing the maintenance of transcriptional repression in the absence of the initiating signal. Although PREs in Drosophila are well characterized, the existence of mammalian PRE-like elements remains debated. Accu...
ORGANISM(S): Homo sapiens 
2016-07-26 | E-GEOD-81795 | biostudies-arrayexpress
Transcriptomicstrx regulatory gene network in D. melanogaster
This SuperSeries is composed of the following subset Series: GSE8748: Chromosomal clustering of genes in trithorax (trx) mutant larvae GSE8750: Chromosomal clustering of genes in absent, small, or homeotic discs 2 (ash2) mutant larvae Keywords: SuperSeries Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8783 | biostudies-arrayexpress
TranscriptomicsChromosomal clustering of genes in trithorax (trx) mutant larvae
We have performed a systematic examination of genome-wide expression profiles using microarrays to reconstruct a global picture of the trx regulatory gene network in D. melanogaster. Using computational analysis of the microarray data, we have identified 25 clusters of genes potentially regulated by...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8748 | biostudies-arrayexpress
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1 conformation and activity
We have demonstrated that site-directed mutagenesis in ADAM17 (ADAM17cytoF730A) also disrupts the interacting interface with Trx-1, resulting in a decrease of Trx-1 reductive capacity and activity. One of the mechanisms that explain this effect might be that ADAM17cyto favors Trx-1 monomerization st...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD015431 | Pride
Adam17 Thioredoxin-1 Mass spectrometry Redox signaling. Dimerization Iodotmt 
ProteomicsADAM17 cytoplasmic domain modulates Thioredoxin-1
We have previously shown that Thioredoxin-1 (Trx-1) binds to the cytoplasmic domain of ADAM17 (ADAM17cyto), A Disintegrin And Metalloprotease 17, and that the destabilization in their interface of interaction favors the Trx-1 dimeric and inactive state. These studies opened the question of whether A...
ORGANISM(S): Homo Sapiens 
2021-03-12 | PXD020016 | panorama
TranscriptomicsTRX-1 Regulates SKN-1 Nuclear Localization Cell Non-Autonomously in Caenorhabditis elegans
The Caenorhabditis elegans oxidative stress response transcription factor, SKN-1, is essential for the maintenance of redox homeostasis and is a functional ortholog of the Nrf family of transcription factors. The numerous levels of regulation that govern these transcription factors underscore their ...
ORGANISM(S): Caenorhabditis elegans 
2016-04-01 | E-GEOD-77976 | biostudies-arrayexpress
TranscriptomicsChromosomal clustering of genes in absent, small, or homeotic discs 2 (ash2) mutant larvae
We have performed a systematic examination of genome-wide expression profiles using microarrays to reconstruct a global picture of the trx regulatory gene network in D. melanogaster. Using computational analysis of the microarray data, we have identified 25 clusters of genes potentially regulated by...
ORGANISM(S): Drosophila melanogaster 
2010-06-25 | E-GEOD-8750 | biostudies-arrayexpress
TranscriptomicsDrosophila Oga deletion perturbs O-GlcNAcylation of chromatin factors
Drosophila development is a complex and dynamic process regulated, in part, by members of the Polycomb (Pc), Trithorax (Trx) and Compass chromatin modifier complexes. O-GlcNAc Transferase (OGT/SXC) is essential for Pc repression suggesting that the O-GlcNAcylation of proteins plays a key role in re...
ORGANISM(S): Drosophila melanogaster 
2016-07-21 | E-GEOD-74846 | biostudies-arrayexpress
GenomicsAn epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS
An epigenetic mark of polycomb response elements implemented by Trx/MLL/COMPASS
PRJNA322547 | ENA
GenomicsTrx knockdown in intestinal stem cells (ISCs) of Drosophila melanogaster
Trx knockdown in intestinal stem cells (ISCs) of Drosophila melanogaster
PRJNA686011 | ENA
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