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ProteomicsClinical Proteomics of Metastatic Melanoma Reveals Profiles of Organ-Specificity and Treatment Resistance
Immunotherapy and targeted therapy dramatically changed the treatment of metastatic melanoma. Yet, many patients do not respond to these treatments and improve the understanding of response and resistance is an urgent need. Thus, we utilized mass spectrometry-based proteomic analysis of 185 metastat...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020618 | Pride
Melanoma Braf Metastases Proteomics Immunotherapy 
ProteomicsPROMIS-Quan: a novel proteomic method for plasma biomarker quantification
Unbiased proteomic analysis of plasma samples holds the promise to reveal clinically invaluable disease biomarkers. However the tremendous dynamic range of the plasma proteome has so far hampered the identification of such low abundant markers. To overcome this challenge we analyzed the plasma micro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080835 | MassIVE
ProteomicsProteomics of melanoma response to immunotherapy reveals dependence on mitochondrial function
Immunotherapy has revolutionized cancer treatment, yet most patients do not respond. Here, we investigated mechanisms of response by deeply profiling the proteome of clinical samples from advanced stage melanoma patients undergoing either tumor infiltrating lymphocytes (TIL)-based or anti-PD1 immuno...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD006003 | Pride
Human Melanoma Lc-ms/ms 
ProteomicsPDZD8 interacts with Protrudin and Rab7 to form an ER-late endosome membrane contact site that recruits mitochondria
Endosomes regulate a plethora of cellular processes including signaling, nutrient status and organelle quality control by controlling the fate of material entering the cells. Endosomes undergo a process of maturation which specifies whether material will be shuttled back to the cell surface or degra...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD015523 | Pride
Human Ls-ms/ms Q exactive plus 
ProteomicsClinical Proteomics of Breast Cancer Unravels a Novel Layer of Breast Cancer Classification
Breast cancer classification has been in the focus of numerous large worldwide efforts, analyzing the molecular basis of breast cancer subtypes, aiming to associate them with clinical outcome and improve the current diagnostic routine. Genomic and transcriptomic profiles of breast cancer have been w...
ORGANISM(S): Homo sapiens (Human) 
2019-07-29 | PXD009766 | Pride
Lc-ms Proteomics Breast cancer classification Breast cancer subtypes 
TranscriptomicsGene expression profiling in the developing neural tube
At an incidence of approximately 1/1000 births, neural tube defects (NTDs) comprise one of the most common and devastating congenital disorders. In an attempt to enhance and expand our understanding of neural tube closure, we undertook a high-throughput gene expression analysis of the neural tube as...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-39442 | biostudies-arrayexpress
ProteomicsPROMIS-Quan: a novel proteomic method for plasma biomarker quantification
Unbiased proteomic analysis of plasma samples holds the promise to reveal clinically invaluable disease biomarkers. However the tremendous dynamic range of the plasma proteome has so far hampered the identification of such low abundant markers. To overcome this challenge we analyzed the plasma micro...
ORGANISM(S): Homo sapiens (Human) 
2015-01-28 | PXD001194 | Pride
Plasma Microparticles Super-silac Biomarkers 
ProteomicsA systematic multi-omics investigation of breast cancer metabolism mapping its tiered regulation
Altered metabolism is a hallmark of cancer, but little is still known about its regulation. Here we measure transcriptomic, proteomic, phospho-proteomic and fluxomics data in a breast cancer cell-line across three different conditions. Integrating these multiomics data within a genome scale human me...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD006449 | Pride
Phosphoproteomics Breast cancer Proteomics Metabolomics Metabolic modeling 
ProteomicsUMSBP2 is chromatin remodeler that functions in regulation of gene expression and suppression of antigenic variation in trypanosomes
Universal Minicircle Sequence binding proteins (UMSBPs) are CCHC-type zinc-finger proteins that bind the single-stranded G-rich UMS sequence, conserved at the replication origins of minicircles in the kinetoplast DNA, the mitochondrial genome of trypanosomatids. Trypanosoma brucei UMSBP2 has been re...
ORGANISM(S): Trypanosoma brucei 
2023-07-20 | PXD030439 | Pride
Trypanosomes Antigenic variation Gene expression Umsbp Chromatin remodeling 
OtherPROMIS-Quan: a novel proteomic method for plasma biomarker quantification
Data from ProteomeXchange, PXD ID: PXD001194. File: Animal_20141209_MH_MPs_PC_9.mzml. Published as part of Mol Cell Proteomics. 2015 Jan 26 . From the Abstract: {{i}} To overcome this challenge we analyzed the plasma microparticle proteome, and reached an unprecedented depth of over 3,000 plasma pr...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320007536 | GPMDB
Resource Reanalysis 
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