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ProteomicsQuantitative proteomics of nutrient starved wildtype (WT) and MTM1 knock out (KO) HeLa cells.
Quantitative whole cell proteomics that compare fed or starved wildtype (WT) and MTM1 KO HeLa cells.
ORGANISM(S): Homo sapiens (Human) 
2022-12-22 | PXD033850 | Pride
Lc-ms Starvation Hela Tmt-labeling Mtm1 
ProteomicsAPEX2 proximity labeling of PI(3)P dependent ER and early endosome membrane contact tether proteins
To understand the nature of ER and early endosome membrane contact site, we capitalized the MTM1 knock out (KO) HeLa cells that do not dissociate the ER and early endosome membrane contact upon nutrient starvation. By using the Doxycyclin inducible APEX2 fused Rab5A (early endosome marker) expressin...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD033846 | Pride
Hela Apex2 Lc-ms Mtm1 Early endosome Er Membrane contact 
ProteomicsIdentification of nutrient dependend PIK3C2B regulators
To identify factors responsible for the differential localization and activity of PIK3C2Bin the presence or absence of serum mitogens we took a quantitative functional proteomics approach based on stable isotope labeling of amino acids in cell culture (SILAC). Genome-engineered HEK293T cells endogen...
ORGANISM(S): Homo sapiens (Human) 
2019-10-02 | PXD014533 | Pride
Pik3c2b 
ProteomicsDetermination of PIK3C2B binding small GTPases
Identify small GTPases of the Rab family of small GTPases that regulate PIK3C2B
ORGANISM(S): Homo sapiens (Human) 
2019-10-02 | PXD014530 | Pride
Pi3 kinase Rab gtpase 
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
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