Hdac2 - OmicsDI

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State Key Lab of Reproductive Medicine, Nanjing Medical University (2)
1. College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling 712100, Shaanxi, China; 2. Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling 712100, Shaanxi, China (1)
Aix-Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM), Turing Center for Living Systems, Marseille, France (1)
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Claude Asselin, Université de Sherbrooke, Department of immunology and Cell Biology, Faculty of medicine and Health Sciences, Université de Sherbrooke (lab head) (1)
Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald 17475 Greifswald (Postadresse) Germany (1)
Dr. Elke Hammer Universitätsmedizin Greifswald Interfakultäres Institut für Genetik und Funktionelle Genomforschung Abteilung für Funktionelle Genomforschung Felix-Hausdorff-Straße 8 17487 Greifswald Germany (1)
Head of Discovery Proteomics Facility Oxford (1)
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Immune Regulation and Cancer, Berlin, Germany (1)
Medical University of Vienna, Center for Anatomy and Cell Biology, Division for Cell and Developmental Biology, Vienna, Austria (1)
Molecular Proteomics Laboratory (MPL) Biologisch-Medizinisches Forschungszentrum (BMFZ) Heinrich-Heine-Universität Düsseldorf (1)
School of Biosciences Firth Court, Western Bank University of Sheffield Sheffield, S10 2TN United Kingdom (1)
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St. Anna Children's Cancer Research Institute (CCRI), Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria. (1)
UMR 1095 GDEC, INRA Clermont Ferrand, Blaise Pascal University Aubière, FRANCE (1)
University of Pennsylvania (1)
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Université de Sherbrooke (1)

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The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis

Histone deacetylases (Hdac) remove acetyl groups from proteins, influencing global and specific gene expression. Hdacs control inflammation, as shown by Hdac inhibitor-dependent protection from DSS-induced murine colitis. While tissue-specific Hdac knockouts show redundant and specific functions, li...

ORGANISM(S): Mus musculus

2014-02-08 | E-GEOD-54785 | biostudies-arrayexpress

Quantitative proteomic TandemMassTag analysis of intestinal epithelial cells (IEC) deleted for both Hdac1 and Hdac2

We have performed quantitative proteomic TandemMassTag to investigate proteomic changes after deletion of epigenetic eraser genes Hdac1 and Hdac2 in intestinal epithelial cells. Both HDAC1 and HDAC2 are epigenetic erasers that drive specific and redundant gene expression patterns, in part by removin...

ORGANISM(S): Mus musculus (Mouse)

2021-09-09 | PXD022558 | Pride

Quantitative proteomic SILAC analysis of enteroids deleted for Hdac1 or Hdac2

We have exploited organoid SILAC approaches that we have previously developed (A SILAC-Based Method for Quantitative Proteomic Analysis of Intestinal Organoids.- Gonneaud A, Jones C, Turgeon N, Lévesque D, Asselin C, Boudreau F, Boisvert FM. -Sci Rep. 2016 Nov 30;6:38195. doi: 10.1038/srep38195) to ...

ORGANISM(S): Mus musculus (Mouse)

2019-11-14 | PXD011869 | Pride

Intestin Hdac2 Enteroid Silac Hdac1

Effect of HDAC2 siRNA on HCC

Determine the effect and specificity of HDAC2 siRNA compared to SAHA inhibition of HDAC2 in hepatocellular carcinoma (HCC) Profile of treated cells compared to control Transcriptomic profiling

ORGANISM(S): Homo sapiens

2014-10-02 | E-GEOD-52232 | biostudies-arrayexpress

HOP homeobox (Hopx) and Histone deacetylase-2 (Hdac2) deficiency effect on the embryonic heart

Analysis of heart ventricles from Hopx, Hdac2, and both Hopx-Hdac2 deficient embryos at embryonic day E16.5. Results provide insight into the role of Hopx and Hdac2 in cardiac development. We used microarrays to detail the global programme of gene expression underlying cardiac development by Hopx an...

ORGANISM(S): Mus musculus

2010-08-19 | E-GEOD-23700 | biostudies-arrayexpress

Transcription profiling of mouse HDAC2 knockout myocardium

We used microarrays to detail the global programme of gene expression underlying cardiac development by HDAC2 and identified distinct classes of up-regulated and down-regulated genes during this process. Experiment Overall Design: Embryonic heart ventricles were dissected at E17.5 for RNA extraction...

ORGANISM(S): Mus musculus

2008-06-15 | E-GEOD-6770 | biostudies-arrayexpress

MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma.

MYCN is a master regulator controlling many processes necessary for tumor cell survival. Here, we unravel a microRNA network that causes tumor suppressive effects in MYCN-amplified neuroblastoma cells. In profiling studies, histone deacetylase (HDAC) inhibitor treatment most strongly induced miR-183...

ORGANISM(S): Homo sapiens

2013-05-01 | E-GEOD-44538 | biostudies-arrayexpress

Functions of HDAC1 and HDAC2 in Schwann cells during postnatal

The aim of our study is to determine the functions of histone deacetylases (HDACs) 1 and 2 in Schwann cells during postnatal development of the peripheral nervous system (PNS). Schwann cells are the myelinating glial cells of the PNS. At birth, mouse sciatic nerves mature in 2 subsequent phases: 1/ ...

ORGANISM(S): Mus musculus

2011-02-25 | E-GEOD-27451 | biostudies-arrayexpress

Primary human erythroid progenitor cells HDAC1 and HDAC2 shRNA knockdown samples

Gene expression profiling was performed on primary human erythroid progenitor cells expressing a control shRNA (luciferase), two different HDAC1 shRNAs, and two different HDAC2 shRNAs. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year ...

ORGANISM(S): Homo sapiens

2010-07-29 | E-GEOD-22366 | biostudies-arrayexpress

HDAC2 Mediates Gene Inactivating of p16INK4a and Promotes Gastric Carcinogenesis by Enhancing Cell Survival and Growth

To investigate the specific roles of HDAC2 in the development of gastric cancer, we employed large-scale gene expression analysis to identify the molecular signature that may affect enabling characteristics of cancer cells. Differentially expressed genes were analyzed on the MKN-1 cells transfected ...

ORGANISM(S): Homo sapiens

2011-08-16 | E-GEOD-31338 | biostudies-arrayexpress

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