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MetabolomicsIntegrated Multi-omics Elucidation of the Uric Acid Degradation Pathway in Limosilactobacillus fermentum M5e

Hyperuricemia is a growing global health concern associated with gout, renal diseases, and cardiovascular disorders. Current pharmacotherapies are often limited by side effects, underscoring the need for alternative strategies. In this study, we isolated Limosilactobacillus fermentum M5...

2026-01-26 | MTBLS13223 | MetaboLights
ProteomicsDIA anaylsis for human plasma in MI patitents
A total of 386 patients were enrolled from May 2019 to May 2022 in TEDA International Cardiovascular Hospital, Tianjin, China. This study was approved by Institutional Review Board (IRB) at TEDA International cardiovascular hospital, Tianjin, china, and informed consent was obtained from all patient...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD056463 | Pride
Dia Mi Human plasma 
ProteomicsYTHDF2 regulates self non-coding RNA metabolism to control TLR3 activation in Inflammation
To elucidate the roles of YTHDF2 in the UV response in Human Keratinocyte (HaCaT) cells, the YTHDF2 interactome was analyzed through immunoprecipitation using a YTHDF2-specific antibody. Control IgG served as a negative control in this study. The cells were treated with UVB at 20 mJ/cm², and one hou...
ORGANISM(S): Homo sapiens (Human) 
2025-09-10 | PXD059422 | Pride
U6 Cancer Ythdf2 Tlr3 Inflammation M6a Snrna Rna methylation Uvb 
UnknownMenin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Not available
S-EPMC6994154 | biostudies-literature
TranscriptomicsProgramming and inheritance of parental DNA methylomes in mammals
The reprogramming of parental methylomes is essential for embryonic development. In mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted to oxidized bases. These paternal oxidized bases and maternal 5mCs are believed to be passively diluted by cell divisions. By gen...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-56697 | biostudies-arrayexpress
UnknownCircMap4k2 reactivated by aneurysm plication alleviates residual cardiac remodeling after SVR by enhancing cardiomyocyte proliferation in post-MI mice.
Not available
S-EPMC11518968 | biostudies-literature
TranscriptomicsPhenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice [Expression array].
Evidence suggests that epigenetic perturbations are involved in the adverse effects associated with some drugs and toxicants, including certain classes of non-genotoxic carcinogens. Such epigenetic changes (altered DNA methylation and covalent histone modifications) may take place at the earliest st...
ORGANISM(S): Mus musculus 
2011-12-14 | E-GEOD-34423 | biostudies-arrayexpress
ProteomicsCount Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler’s Documents by EVA Technology and Mass Spectrometry
The interest of scientists in analysing items of World Cultural Heritage, has been exponentially increasing since the beginning of the new millennium. These studies have grown considerably in tandem with the development and the use of sophisticated and sensitive technologies such as the high-resolut...
ORGANISM(S): Homo sapiens (Human) 
2023-08-23 | PXD041350 | Pride
Eva diskettes Ancient proteins Mass spectrometry Vlad the impaler Dracula 
TranscriptomicsSperm but not oocyte DNA methylome is inherited by zebrafish early embyros
5-methylcytosine is a major epigenetic modification sometimes called "the fifth nucleotide". However, our knowledge of how offspring inherit the DNA methylome from parents is limited. We generated nine single-base resolution DNA methylomes including zebrafish gametes and early embryos. The...
ORGANISM(S): Danio rerio 
2013-05-20 | E-GEOD-44075 | biostudies-arrayexpress
ProteomicsMouse Kidney TMT Quantitative Proteomics
We extracted proximal renal tubules of WT and Lonp1-cKO mice (n=3), and then performed isobaric tags for relative and absolute quantification (iTRAQ)-based quantitative proteomic analysis to assess differential protein-expression levels.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-09 | PXD037552 | Pride
Lc-ms/ms Mouse Kidney 
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