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ProteomicsPhosphoproteomic analysis of T cell receptor stimulation-induced changes in human primary CD4+CD25- T cells in the absence or presence of regulatory T cells.
This is an addition to dataset PXD004291. This data were only used for confirmation of certain phosphopetides. The dataset was not included in inital analysis due to suboptimal sample preparation.
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD006142 | Pride
T-cells Phosphoproteomics 
ProteomicsPhosphoproteomic analysis of T cell receptor stimulation-induced changes in human primary CD4+CD25- T cells in the absence or presence of regulatory T cells.
Regulatory T cells (Tregs) suppress other immune cells and are indispensable for human health, yet the molecular mechanisms of suppression remain incompletely understood. Tregs can suppress proliferation and cytokine production of CD4+CD25- conventional T cells (Tcons). We previously demonstrated th...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD004291 | Pride
Co-cultures Regulatory t cells (tregs) Ti-imac Human cd4+ t cells Phosphoproteomics 
ProteomicsTi4+-IMAC label-free quantification
We combine high-resolution mass spectrometry with Ti4+-IMAC phosphopeptide enrichment and label-free quantification to monitor the phosphoproteome of Jurkat T-cells following stimulation by Prostaglandin E2. Jurkat T lymphoma cells were grown in RPMI 1640 medium supplemented with 10% fetal bovine se...
ORGANISM(S): Homo sapiens (Human) 
2014-05-22 | PXD000293 | Pride
Label-free phosphoproteomics 
OtherHuntingtin associated protein (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP), specific for the cGMP-dependent protein kinase Iβ isoform.
Data from ProteomeXchange, PXD ID: PXD001434. Published as part of J Biol Chem. 2015 Feb 4. pii . From the Abstract: {{i}} ... Here, we extend on this cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary in...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320007631 | GPMDB
Resource Reanalysis 
ProteomicsLC/MS label-free analysis of disulfide bond in C. bovis DnaA DI mutant S89C, Schumacher lab
Analysis of recombinant DnaA mutant construct with emphasis on identifying a natural disulfide occurence, detection done by crosslinking analysis via LC/MS-MS DDA on an Orbitrap Astral
ORGANISM(S): Bos taurus (Bovine) 
2026-06-29 | PXD074582 | Pride
Disulfide Orbitrap astral Label-free 
ProteomicsProteomic analysis of T cell differentiation
T helper cells (Th) play an important role guarding, regulating and modulating immune responses. The different Th lineages fulfill different tasks in response to infections. The two best defined subtypes are Th1 (involved in cellular immunity) and Th2 (humoral immunity). The cytokine environment aft...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-14 | PXD004532 | Pride
Th2 Th1 Murine cd4+ t- cells Q exactive Scx 
ProteomicsProteogenomic systems analysis identifies targeted therapy resistance mechanisms in EGFR-mutated lung cancer
Cancer precision medicine largely relies on knowledge about genetic aberrations in tumors and next-generation-sequencing studies have shown a high mutational complexity in many cancers. Although a large number of the observed mutations is believed to be not causally linked with cancer, the functiona...
ORGANISM(S): Homo sapiens (Human) 
2018-07-02 | PXD009996 | Pride
Lung cancer Proteomic System biology Drug resistance 
ProteomicsMultiple protease based human phosphopeptide atlas
Site-specific phospho-antibodies are commonly used to study these changes, however only a limited number of good antibodies is available, covering just a few signaling nodes in important pathways. It is highly unlikely that specific antibodies, covering the more than hundred thousands of estimated p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080223 | MassIVE
ProteomicsA molecular model of sea urchin reversible adhesion based on quantitative proteomics
Marine bioadhesives have unmatched performances especially in wet environments, being valuable sources of inspiration for industrial and biomedical applications. In sea urchins specialized adhesive organs, called tube feet, mediate adhesion. These are composed by a disc, which produces adhesive and ...
ORGANISM(S): Paracentrotus lividus (Common sea urchin) 
2016-03-21 | PXD003122 | Pride
Sea urchin Echinoderm Tube foot adhesive protein Reversible adhesion Paracentrotus lividus Quantitative proteomics 
ProteomicsPersonalized proteome profiles of healthy and tumor human colon organoids reveal both individual diversity and basic features of colorectal cancer.
We performed quantitative mass spectrometry based proteomic analysis and comparative transcriptomics analysis of 7 individual patient-derived human colorectal tumor and healthy organoids, the latter acquired from adjacent healthy tissue.
ORGANISM(S): Homo sapiens (Human) 
2017-01-16 | PXD004149 | Pride
Proteomics Organoids Colon cancer 
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