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TranscriptomicsExpression data from colon fibroblasts treated with Sonic hedgehog homolog (SHH)
Canonical Hedgehog (Hh) signaling regulates the expression of genes that are critical to the patterning and development of a variety of organ systems. In adult, both ligand-dependent and ligand-independent Hh pathway activation are known to promote tumorigenesis. Recent studies have shown that in tu...
ORGANISM(S): Homo sapiens 
2011-05-17 | E-GEOD-29316 | biostudies-arrayexpress
TranscriptomicsHistone deacetylase 6 exerts dichotomous effects on the Hedgehog signaling cascade
Murine embryo fibrablosts from stably transfected with Sonic Hedgehog were treated with siRNA and their transcription profiles captured.
ORGANISM(S): Mus_musculus 
2015-01-26 | E-MTAB-2440 | biostudies-arrayexpress
TranscriptomicsGene expression in mice with conditional over-activation of hedgehog signaling in the ovary
The objective of the study was to determine the cause of anovulation in transgenic mice with conditional over-activation of the hedgehog signaling pathway in the ovary. In Amhr2(cre/+)-SmoM2 transgenic mice, a constitutively active version of the hedgehog signal transducer, smoothened (SMO), known ...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-35123 | biostudies-arrayexpress
ModelsSivakumar2011 - Hedgehog Signaling Pathway
Sivakumar2011 - Hedgehog Signaling Pathway This is the current model for the Hedgehog signaling pathway. The best data for mechanism of signaling has been worked out in Drosophila, so this model is based largely on Drosophila data. Hedgehog target genes vary from tissue to tissue, so the ident...
2024-09-02 | BIOMD0000000395 | BioModels
TranscriptomicsGene expression profiling of conditional ablation of Indian hedgehog in the mouse uterus
Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile due to defects in embryo implantation. We performed microarray analysis on these mice at the time point at which the Ihh target genes are induced by the administration of exogenous hormone to mimic d...
ORGANISM(S): Mus musculus 
2010-03-06 | E-GEOD-19517 | biostudies-arrayexpress
ProteomicsPP2A Phosphatase Regulatory Subunit PPP2R3C is a New Positive Regulator of the Hedgehog Signaling Pathway
Cellular signaling pathways rely on posttranslational modifications (PTMs) to finely regulate protein functions, particularly transcription factors. The Hedgehog (Hh) signaling cascade, crucial for embryonic development and tissue homeostasis, is susceptible to aberrations that lead to developmental...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-10 | PXD054802 | Pride
Ppp2r3c  pp2a  phosphatases  hedgehog signaling  gli  phosphorylation  
ProteomicsPhosphoproteomics of induced and inhibited early Hh signaling in human medulloblastoma cells
Aberrant sonic hedeghog signaling is implicated in the development of various cancer entities such as medulloblastoma. The canonical signaling cascade has been studied for years. Activation of GLI transcription factors was revealed as the driving force upon pathway activation. Phosphorylation by Pro...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013408 | Pride
Phosphoproteomics Medulloblastoma Daoy cells Hedgehog signaling Phosphorylation 
TranscriptomicsSynergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma (Daoy) cells
Aberrant activation of Hedgehog (HH) signaling has been identified as a key etiologic factor of many human malignancies. Signal strength, target gene specificity, and oncogenic activity of HH signaling profoundly depend on interactions with other pathways such as epidermal growth factor receptor-med...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-46045 | biostudies-arrayexpress
ProteomicsParalogue specific TTC30A knockout downregulates Sonic hedgehog signaling
Cilia assembly, maintenance and the localization of signal-transduction proteins necessitate a functioning intraflagellar transport (IFT). The IFT machinery moves cargo along a microtubule scaffold from the proximal to the distal end of the cilium. This anterograde transport is facilitated by a larg...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044183 | Pride
Ttc30 paralogues Sonic hedgehog signaling Affinity proteomics Ift Pka Cilia 
TranscriptomicsTranscriptional responses to Sonic Hedgehog pathway stimulation in in vitro derived neural progenitors
The objective of this study was to identify genes regulated by Sonic Hedgehog pathway stimulation in neural progenitors. Paired (parallel culture) triplicates of neuralized embryoid body cultures with and without Shh pathway stimulation (Ag1.3-treatment)
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42565 | biostudies-arrayexpress
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