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ProteomicsProteomic analysis of Giardia lamblia ESV and PV organelle enriched fractions
The protozoan Giardia lamblia is a unique biological model to investigate minimal cellular mechanisms because it is an early‐diverged eukaryote that has undergone reductive evolution and has minimized or lost organelles such as mitochondria, peroxisomes, the endo-lysosomal system and a Golgi apparat...
ORGANISM(S): Giardia lamblia ATCC 50803 
2014-03-11 | PXD000694 | Pride
Flow cytometry assisted organelle sorting Organelle proteomics Giardia Encystation Endocytosis 
ProteomicsToxoplasma gondii aspartyl protease 3
The micronemes and rhoptries are specialized organelles that secrete their contents at the apical tip of apicomplexan parasites in a sequential and regulated manner. Microneme and rhoptry proteins crucially participate in motility, invasion, and egress from infected cells. They first traffic through...
ORGANISM(S): Toxoplasma gondii 
2018-01-30 | PXD006235 | Pride
Protease substrate screen Positional proteomics Tails 
ProteomicsAnalysis of the Babesia canis secreted proteome during virulent infection
Secreted parasite factors from Babesia canis during acute infection were investigated using a LC-MS/MS assay which led to the discovery of potential pathogenicity factors. Combined data from genomics, transcriptomics and proteomics provide a first predicted and partially validated set of potential v...
ORGANISM(S): Babesia canis canis Babesia canis 
2017-06-16 | PXD005117 | Pride
Canine babesiosis Pathogenicity factors Shot-gun ms Babesia canis Secretome 
ProteomicsThe interactomes of GlFYVE PIP-binding protein in Giardia lamblia
We investigated the composition of the interactomes of 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers to GlFYVE.
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013897 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsThe interactomes of GlPXD2 and 4 PIP-binding proteins in Giardia lamblia
We investigated the composition of the interactomes of overall 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers to proteins GlPXD2 and 4
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013899 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsThe interactomes of GlNECAP PIP-binding proteins in Giardia lamblia
We investigated the composition of the interactomes of 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers GlNECAP.
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013896 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsSerial co-immunoprecipitation to expand the protein interactome of the outer mitosomal membrane in Giardia lamblia
Giardia lamblia's outer mitosomal membrane protein repertoire was investigated using a series of co-immunoprecipitations which led to the discovery of novel associated components. This was assembled into a Giardia mitosomal protein interactome which expands beyond the organelle, reaching out to othe...
ORGANISM(S): Giardia lamblia ATCC 50803 
2016-11-15 | PXD004583 | Pride
Crosslinking Protein discovery 
ProteomicsCo-immunoprecipitation of HA-tagged proteins in Giardia lamblia
Giardia lamblia's diverged endocytic system was investigated using co-immunoprecipitation of known and conserved endocytic factors which led to the discovery of novel associated components. This was assembled into an interactome of the endocytic pathway in this intestinal parasite.
ORGANISM(S): Giardia lamblia ATCC 50803 
2016-06-23 | PXD003718 | Pride
Co-immunoprecipitation  clathrin  endocytosis  giardia lamblia 
ProteomicsTarget identification of the novel Toxoplasma gondii rhoptry kinase RON13
The Toxoplasma gondii rhoptry neck protein RON13 was first identified as a substrate of aspartyl protease 3 by Terminal Amine Isotopic Labelling of Substrates (TAILS8, Dogga et al. 2017). It harbours a kinase domain the activity of which is important for host cell invasion. To identify the targets o...
ORGANISM(S): Toxoplasma gondii RH 
2021-05-13 | PXD018056 | Pride
Rhoptry Toxoplasma gondii Kinase Lc-ms/ms 
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