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ProteomicsSecretome of human PBMC after ConA stimulation and incubation with A1 and A2 milk fractions of different molecular weight
There is an ongoing discussion about cow’s milk and its variants primarily focusing on the A1 variant in contrast to the A2 variant and their health-related impacts. The difference between these variants lies in a single amino acid alteration at position 67 of β-casein. This alteration is presumed t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD066232 | Pride
A1/a2 milk Uantitative label-free lc-ms/ms Modulation of immune system Human pbmc 
UnknownSingle hormone or synthetic agonist induces Gs/Gi coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Not available
S-EPMC10372679 | biostudies-literature
ProteomicsReprograming of Proteasomal Degradation by Branched Chain Amino Acid Metabolism
Branched chain amino acids (BCAAs) play an important role in energy and protein regulation. Defects in BCAA metabolism are linked to numerous pathologies, including diabetes, neurodegeneration, and premature aging. Isovaleric acidemia is a metabolic disease caused by defective leucine breakdown and ...
ORGANISM(S): Caenorhabditis elegans 
2022-09-22 | PXD028286 | Pride
C. elegans  ubiquitin  leucine catabolism  branched chain amino acid (bcaa)  bcat  ivd  isovaleric acidemia 
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
UnknownProgression of QRS duration - a potential surrogate marker of survival in ATTRwt amyloidosis patients.
Not available
S-EPMC12539068 | biostudies-literature
ProteomicsSpatial centrosome proteome of human neural cells uncovers novel interactors and disease hubs
Despite the crucial importance of the centrosome in brain development and disease, its comprehensive proteome remains uncharacterized in neural cells. Here, we used spatial proteomics to elucidate protein interaction networks at the centrosome of iPSC-derived human neural stem cells (NSCs) and neuro...
ORGANISM(S): Homo sapiens (Human) 
2022-06-22 | PXD031936 | Pride
Neuron Neural stem cells Neurodevelopmental disorder Human brain Rna splicing Centrosome Interactome 
ProteomicsOverexpression of the human mutation P209L of cochaperone BAG3 in mouse
An amino acid exchange (P209L) in the HSPB8 binding site of the human cochaperone Bcl2-associated athanogene 3 (BAG3) gives rise to severe dominant childhood cardiomyopathy. To phenocopy the disease in mouse and gain insight into its mechanisms, we have generated humanized transgenic mouse models. E...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD021165 | Pride
Heart Human bag3 p209l Mouse 
ProteomicsProteomic analysis of histone modifications present on nucleosomes bound by INO80 complex
The INO80 complex is a chromatin remodeler that regulates DNA replication, repair, and transcription. Although the INO80 complex plays a crucial role in various chromatin-associated processes, the mechanism of its recruitment to specific genomic loci is not well understood. Here we used a native ChI...
ORGANISM(S): Homo sapiens (Human) 
2023-12-10 | PXD042210 | Pride
Native chip-ms Ino80 Histone ptms 
ProteomicsDisassembly of Functional Membrane Microdomains Relapses Antibiotic Resistance in Staphylococcus aureus
Bacteria spatially confine cellular processes like protease secretion and signal transduction in membrane platforms termed functional membrane microdomains, which in certain organisational and functional features resemble the lipid rafts of eukaryotic cells. However, a rigorous understanding of thei...
ORGANISM(S): Staphylococcus aureus 
2019-01-08 | PXD006546 | Pride
Drm Dsm Membrane platforms Staphylococcus aureus Lc-ms/ms 
UnknownThe P5-type ATPase ATP13A1 modulates major histocompatibility complex I-related protein 1 (MR1)-mediated antigen presentation.
Not available
S-EPMC8808182 | biostudies-literature
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