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ProteomicsDepletion Assisted Hemin Affinity (DAsHA) Proteomics Reveals an Expanded Landscape of Heme Binding Proteins in the Human Proteome
Heme b (iron protoporphyrin IX) plays important roles in biology as a metallocofactor and signaling molecule. However, the targets of heme signaling and the network of proteins that mediate the exchange of heme from sites of synthesis or uptake to heme dependent or regulated proteins are poorly unde...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD037165 | Pride
Heme Heme trafficking Proteomics Heme binding protein Cell stress Heme affinity Hemin agarose Labile heme pool 
ProteomicsHow the presence of hemin affects the expression of all iron-uptake pathways in Pseudomonas aeruginosa cells
Iron is an essential nutriment for almost all organisms, but this metal is poorly bioavailable. During infection, bacteria access iron from the host by importing either iron or hemin. Pseudomonas aeruginosa, a Gram-negative pathogen, secretes two siderophores, pyoverdine (PVD) and pyochelin (PCH), t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-03-15 | PXD028818 | Pride
Pseudomonas Hemin Iron uptake pathway 
ProteomicsCharacterization of Metronidazole-tolerant Porphyromonas gingivalis Persisters
This project investigated the phenotypic characteristics of Metronidazole-tolerant Porphyromonas gingivalis persisters, the relevant modulatory effects of hemin and their underlying survival mechanisms. Proteomic analysis was performed to delineate the protein expression profiles of Metronidazole-to...
ORGANISM(S): Porphyromonas gingivalis ATCC 33277 
2018-08-29 | PXD008976 | Pride
Porphyromonas gingivalis Metronidazole Hemin Persisters Lc-ms/ms 
ProteomicsPhosphoproteomic analysis of Hemin- and Erastin-induced neuronal death
Analysis of the differences in phosphorylation in two ferroptosis subtypes (Hemin vs classical erastin-induced ferroptosis) in neurons, and sensitivity of these changes in phosphorylation levels to treatment with ferroptosis suppressor and MEK inhibitor U0126.
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD029318 | Pride
Erastin Hemin Tmt U0126 Ferroptosis Phosphorylation 
UnknownZippered G-quadruplex/hemin DNAzyme: exceptional catalyst for universal bioanalytical applications.
Not available
S-EPMC8682752 | biostudies-literature
UnknownImproving the anthocyanin accumulation of hypocotyls in radish sprouts by hemin-induced NO.
Not available
S-EPMC9055698 | biostudies-literature
TranscriptomicsThe two-component system ChrSA is crucial for heme tolerance and interferes with HrrSA in heme-dependent gene regulation in Corynebacterium glutamicum
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similar...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2012-10-31 | E-GEOD-37327 | biostudies-arrayexpress
UnknownInvolvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility in <i>Stenotrophomonas maltophilia</i>.
Not available
S-EPMC12772443 | biostudies-literature
UnknownPhotodynamic treatment of Staphylococcus aureus with non-iron hemin analogs in the presence of hydrogen peroxide.
Not available
S-EPMC11187572 | biostudies-literature
ProteomicsHigh Heme Resistance in Serratia plymuthica: Adaptive Mechanisms and Possible Role in Aedes aegypti Midgut Homeostasis
Mosquitoes of the genus Aedes are primary vectors of arboviruses such as dengue, Zika, and chikungunya1. Their ability to transmit pathogens is intrinsically linked to their hematophagous behavior, which presents metabolic challenges, particularly during blood digestion2,3. One major challenge is th...
ORGANISM(S): Serratia plymuthica 
2025-07-07 | PXD062643 | Pride
Heme detoxification Proteomics Oxidative stress Aedes aegypti Serratia plymuthica Midgut microbiota Hemin tolerance 
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