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ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-05-21 | PXD070201 | Pride
5-min cycle time 288 spd High-throughput scp Nanolc-ms/ms 
ProteomicsHigh-Throughput Label-free Single-Cell Proteomics Enabled by Multicolumn NanoLC with a 5-min Cycle Time
Mass spectrometry (MS)-based single-cell proteomics (SCP) enables proteome-wide analysis at single-cell resolution, offering insights into cellular heterogeneity, biological processes, and disease mechanisms. However, conventional nanoLC-MS workflows are constrained by long gradients and low through...
ORGANISM(S): Candida albicans (Yeast) Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli 
2026-08-19 | PXD081782 | Pride
Single-cell proteomics High-throughput Multicolumn nanolc 
ProteomicsA high-sensitivity low-nanoflow LC-MS configuration for high-throughput sample-limited proteomics
This work demonstrates the utility of high-throughput nanoLC-MS and label-free quantification (LFQ) for sample-limited bottom-up proteomics analysis, including single-cell proteomics (SCP).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-12 | MSV000092414 | MassIVE
ProteomicsHigh throughput single-cell proteomics of in-vivo cells
Major advancements in single-cell proteomics (SCP) methodologies have been introduced in recent years, providig highly sensitive sample preparation methods and mass spectrometric technologies. However, most studies present limited throughput and mainly focus on the analysis of cultured cells. To enh...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-07-09 | PXD058457 | Pride
Macrophages Single cell proteomics Fixation Murine Lc-ms Hela Bravo Slice-pasef Timstof Automation 
ProteomicsIntegrated Single-Cell Proteomics Analysis on an Active Matrix Digital Microfluidic Chip
We introduce and implement a comprehensive single-cell proteomics sample pre-treatment solution based on an active matrix digital microfluidics chip(AM-DMF-SCP). This platform accommodates high-throughput single-cell isolation and seamless, non-destructive sample pre-treatment, characterized by its ...
ORGANISM(S): Homo Sapiens 
PXD048434 |
UnknownHigh-Throughput Single-Cell Proteomics of In Vivo Cells.
Not available
S-EPMC12301781 | biostudies-literature
ProteomicsSensitive, high-throughput single-shot HLA-I and HLA-II immunopeptidomics with improved coverage using data dependent parallel accumulation-serial fragmentation mass spectrometry
Phulphagar K, Ctortecka C, Vaca Jacome AS, Klaeger S, Verzani E, Hernandez G, Udeshi ND, Clauser KR, Abelin JG, Carr SA. 2023. Comprehensive, in-depth identification of the human leukocyte antigen HLA-I and HLA-II tumor immunopeptidome can inform the development of cancer immunotherapies. Mass spect...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-03-09 | MSV000091456 | MassIVE
ProteomicsHyperSCP: Combining Isotopic and Isobaric Labeling for Higher Throughput Single-Cell Proteomics
Recent developments in mass spectrometry-based single-cell proteomics (SCP) have resulted in dramatically improved sensitivity, yet the relatively low measurement throughput remains a limitation. Isobaric and isotopic labeling methods have been separately applied to SCP to increase throughput throug...
ORGANISM(S): Homo sapiens (Human) 
2023-07-11 | PXD040455 | Pride
Multiplex Single-cell proteomics High-throughput 
GenomicsHigh-throughput single-cell transcriptomes of the brain of the nudibranch Berghia stephanieae
High-throughput single-cell transcriptomes of the brain of the nudibranch Berghia stephanieae
PRJNA698785 | ENA
TranscriptomicsHigh-throughput single-cell transcriptomes of the brain of the nudibranch Berghia stephanieae
Previously, transcriptomics data for mollusc has been obtained by whole-brain bulk RNA-seq and low-throughput scRNA-seq. We want to construct the first molluscan high-throughput single-neuron transcriptomes for Berghia stephanieae. Around 129,000 cells were collected from 20 brains and the libraries...
ORGANISM(S): Berghia stephanieae 
2022-01-14 | GSE165967 | GEO
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