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ProteomicsHypoxia increases the methylated histones to prevent histone clipping and redistribution of heterochromatin during Raf-induced senescence.
Hypoxia in stem cell niches and inner core of solid tumors contributes to cellular senescence and differentiation inhibition. It directly increases histone methylationby inhibiting the activities of O2-and α-ketoglutarate (α-KG)-dependent histone lysine demethylases. This study is the first to demon...
ORGANISM(S): Homo sapiens (Human) 
2024-11-27 | PXD033971 | Pride
Human Top-down Histone Proteomics 
GenomicsPlasmodium histone H3 clipping
Cathepsin C-like protease regulates DNA replication by histone H3 N-terminal clipping in malaria parasites
PRJEB18114 | ENA
ProteomicsIntestinal Differentiation Involves Cleavage of Histone H3 NTerminal Tails by Multiple Proteases
The proteolytic cleavage of histone tails, also termed histone clipping, has been described as a mechanism for permanent removal of post-translational modifications (PTMs) from histone proteins. Such activity has been ascribed to ensure regulatory function in key cellular processes such as different...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-11 | PXD022171 | Pride
Histone post-translational modifications Clipping 
UnknownUnexpected histone H3 tail-clipping activity of glutamate dehydrogenase.
Not available
S-EPMC3696648 | biostudies-literature
ProteomicsHypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
The long-term impact of systemic hypoxia resulting from Acute Respiratory Distress Syndrome (ARDS) on the function of short-lived innate immune cells is unclear. We show that patients 3-6 months after recovering from ARDS have persistently impaired circulating neutrophil effector functions and an in...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD065461 | Pride
Epigenetics Neutrophil Hypoxia Reprogramming 
ProteomicsHypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
The long-term impact of systemic hypoxia resulting from Acute Respiratory Distress Syndrome (ARDS) on the function of short-lived innate immune cells is unclear. We show that patients 3-6 months after recovering from ARDS have persistently impaired circulating neutrophil effector functions and an in...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD065519 | Pride
Epigenetics Neutrophil Hypoxia Reprogramming 
UnknownThe micronuclear histone H3 clipping in the unicellular eukaryote Tetrahymena thermophila.
Not available
S-EPMC10077241 | biostudies-literature
GenomicsHDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail
HDAC1 has intrinsic protease activity and regulates transcription through clipping histone H3 N-terminal tail
PRJNA1137831 | ENA
ProteomicsA rapid and efficient method for the extraction of histone proteins
Current protocols used to extract and purify histones are notoriously tedious, especially when using yeast cells. Here, we describe the use of a simple filter-aided sample preparation approach enabling histone extraction from yeast and mammalian cells using acidified ethanol, a condition that not on...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-10 | PXD041524 | Pride
N-terminal clipping Histone extratction Fasp 
UnknownHypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence.
Not available
S-EPMC11797049 | biostudies-literature
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