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ProteomicsFunction of the histone N-terminal acetyltransferase Naa40 in DNA damage response
N-alpha-acetyltransferase 40 (NAA40) catalyzes acetylation on the N-terminal tip of histones H4 (N-acH4) and H2A (N-acH2A) harboring the Ser(1)-Gly(2)-Arg(3)-Gly(4) recognition sequence. In addition to the well-known role of N-terminal acetylation in protein degradation and stability, recent studies...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD050981 | Pride
Histone post-translational modifications Histone n-terminal acetylation 
ProteomicsMetabolic regulation of N-terminal acetylation in yeast
N-terminal (Nt) acetylation, catalyzed by N-terminal acetyltransferases (NATs), has emerged as an important co-translational modification in eukaryotes, and involves the transfer of the acetyl moiety from acetyl-CoA (Ac-CoA) to the α-amino group of a nascent polypeptide. Here, we report the first gl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-09-07 | PXD004326 | Pride
Metabolism Acetyl coenzyme a Saccharomyces cerevisiae N-terminal acetylation N-terminomics 
TranscriptomicsTranscription profiling of S. cerevisiae where Histone H2B was mutated to give H2B^3-37 to identify genes regulated by the H2B N-terminal domain
Histone H2B was mutated to give H2B^3-37. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-terminal domain. Ex...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3804 | biostudies-arrayexpress
TranscriptomicsHistone H4 N-terminal tail mutants
A series of yeast carrying K->R mutations in the histone H4 N-terminal tail were profiled by gene expression array in mid-log phase.
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2324 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae H2B^3-32 mutants to investigate the role of hstone H2B N-terminal domain in genome wide transcription
Histone H2B was mutated to give H2B^3-32. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-terminal domain. Ex...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3802 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae H2B K6,11,16,17,21,22G mutant vs. wild type to investigate the role of H2B N-terminal domain in transcription
Histone H2B was mutated to give H2B K6,11,16,17,21,22G. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B N-termi...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3803 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae histone H2Bdelat30-37 mutants vs wild type to determine the role of H2B N terminal domaon in transcription
Histone H2B was mutated to give H2B^30-37. Total RNA from three replicate cultures of wild-type and mutant was isolated and the expression profiles were determined using Affymetrix arrays. Comparisons between the sample groups allow the identification of genes regulated by H2B HBR domain. Experime...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3805 | biostudies-arrayexpress
ProteomicsLinking acetyl-CoA labelling and histone acetylation dynamics for accurate determination of acetylation rates via ordinary differential equations
To study complex biological systems, multi-omics methods have become an important tool. They integrate data from multiple biological layers, such as the metabolome and the proteome, to gain better insights of the processes happening. However, challenges remain both in sample preparation for measurem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051487 | Pride
Human Lc-msms Acetylcoa Ptm Histone Acetylation Hek93t 
ProteomicsGlobal profiling of acetylation reveals a new family with dual-specific lysine and N-terminal acetyltransferase activity in the plastids of Arabidopsis
Protein acetylation is a universally conserved modification occurring on N-termini (N--acetylation, NTA) and on internal lysines residues (-lysine-acetylation, KA). So far, NTA and KA were known to be supported by distinct families of enzymes (NATs and KATs, respectively), despite most of them sha...
ORGANISM(S): Escherichia Coli 
2020-07-07 | PXD015875 | JPOST Repository
ProteomicsA Chemical Acetylation based Mass Spectrometry Platform for Histone Profiling
Here we present a strategy for the identification and quantitation of histone methylation that utilizes nondeuterated acetic anhydride to fully acetylate all free lysine residues prior to digestion with trypsin and analysis by LC-MS/MS.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000086146 | MassIVE
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