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ProteomicsAnalysis of N-Glycosylation for SARS-CoV-2 expressed receptor-binding domain VOCs and membrane protein with LC-MS.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect human cells by first attaching to the ACE-2 receptor via its receptor-binding domain (RBD) in the spike protein. We investigated the influence of N-glycosylation sites of the RBD and the membrane (M) protein on IgG antibody bind...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
PXD048930 | panorama
ProteomicsIn-house packed porous graphitic carbon columns for liquid chromatography-mass spectrometry analysis of N-glycans
Although many reversed and normal stationary phases have been utilised for the separation of N-glycans, porous graphitic carbon (PGC) chromatography has become desirable because of its higher resolving capability, but is difficult to implement in a robust and reproducible manner. Herein, we demonstr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-07-08 | PXD024489 | Pride
Hypercarb Mass spectrometry Pgc Liquid chromatography N-glycan Porous graphitic carbon Lcmsn-glycan 
ProteomicsAltered N-linked Glycosylation in Endometrial Cancer
It has been recognised for a long time that cell surface glycans plays a vital role in the biological process and their altered form can lead to cancer. However, the molecular details and regulatory mechanism between the glycans and cancer is yet not clear. Over the past decade mass spectrometry-bas...
ORGANISM(S): Homo sapiens (Human) 
2020-11-27 | PXD019425 | Pride
Biomarker Lymph node metastasis Endometrial cancer Glycan imaging 
ProteomicsRaw N-glycan MALDI mass spectrometry imaging data on formalin-fixed mouse kidney
The N-glycome was mapped and visualised on formalin-fixed mouse kidney tissue using an ultrafleXtreme MALDI-ToF/ToF MS instrument (Bruker Daltonics).
ORGANISM(S): Mus musculus (Mouse) 
2018-11-02 | PXD009808 | Pride
Formalin-fixed Kidney N-glycan Mouse Maldi Mass spectrometry imaging 
ProteomicsTruncated N-glycans destabilize POMT1 and POMT2 but do not limit cellular O-mannosylation in HEK293 cells
Protein O-mannosylation is initiated by the ER-resident enzymes POMT1 and POMT2, both of which carry multiple N-glycans essential for proper folding and activity. Although congenital disorders of glycosylation type I (CDG-I) disrupt the early N-glycosylation process, their impact on POMT biogenesis ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-02 | PXD073937 | Pride
Alg3  pomt1  pomt2  kiaa1549  n-glycosylation  o-mannosylation 
ProteomicsPomGnt1 deficiency affects N-cadherin mediated cell-cell adhesion
N-glycoproteomic and O-man glycoproteomic analysis of N-cadherin derived from wild-type(WT) and POMGnT1-deficient HEK293T cells. Proteolytic digestion was performed with trypsin or proteinase K. Glycopeptide enrichment was achieved using cotton-HILIC SPE. Glycopeptides were fragmented by HCD.step an...
ORGANISM(S): Human 
2020-04-07 | MSV000085243 | MassIVE
Genomics(CA)n oligonucleotides correct RNA mis-splicing in TDP-43 pathology (II)
(CA)n oligonucleotides correct RNA mis-splicing in TDP-43 pathology (II)
PRJNA1052750 | ENA
Genomics(CA)n oligonucleotides correct RNA mis-splicing in TDP-43 pathology (I)
(CA)n oligonucleotides correct RNA mis-splicing in TDP-43 pathology (I)
PRJNA1028630 | ENA
ProteomicsStimulus-specific Immune Modulation by SARS-CoV-2 Nucleocapsid Correlates with Severe COVID-19
A significant proportion of patients with COVID-19 disease, caused by SARS-CoV-2, develop acute respiratory distress syndrome characterized by pro-inflammatory cytokine secretion and dampened IFN-mediated antiviral response. To uncover the mechanisms by which SARS-CoV-2 drives this dysregulation, we...
ORGANISM(S): Homo sapiens (Human) Severe acute respiratory syndrome coronavirus 2 
2026-06-25 | PXD067631 | Pride
Sars-cov-2 Macrophages Nf-kb pathways Nucleocapsid (n) Pro-inflammatory responses 
ProteomicsGlycosyltransferase POMGnT1 deficiency affects N-cadherin-mediated cell-cell adhesion
Deficiencies in the protein O-mannose β1,2-N-acetylglucosaminyltransferase 1 (POMGNT1), a glycosyltransferase involved in the elongation of classic O-mannosyl glycans, are mainly associated with muscle-eye-brain disease (MEB), a genetically heterogeneous congenital muscular dystrophy with brain and ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-18 | PXD021321 | Pride
Pomgnt1 Pmgt1 Protein o-linked-mannose beta-1 2-n-acetylglucosaminyltransferase 1 Meb Pomgnt1 Mannosylation Muscular dystrophy-dystroglycanopathy Muscle-eye-brain disease Pomgnt1 
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