Sort   by:  
 Page size 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
ProteomicsBreast cancer stem cell-derived tumors escape from γδ T cell immunosurveillance in vivo by modulating γδ T cell ligands
Triple negative breast cancer (TNBC) lacks targeted therapy options. TNBC is enriched in breast cancer stem cells (BCSCs), which play a key role in metastasis, chemoresistance, relapse and mortality. γδ T cells hold great potential in immunotherapy against cancer, and might be an alternative to targ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD039463 | Pride
Breast cancer stem cells Proteomics Tmt Immune-escape Lc-ms Quantitation Immunotherapy Γδ t cells Phosphoantigens Triple negative breast cancer 
UnknownTargeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells.
Not available
S-EPMC11326963 | biostudies-literature
UnknownHuman adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation.
Not available
S-EPMC4188623 | biostudies-literature
UnknownBreast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands.
Not available
S-EPMC10236150 | biostudies-literature
MetabolomicsThe HuMet Repository: Watching human metabolism at work
Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic responses to oral glucose/lipid loads, mixed meals, 36-h fasting, ...
2024-07-23 | MTBLS89 | MetaboLights
TranscriptomicsTranscriptome analysis reveals a major impact of Tyk2 on the expression of interferon responsive and metabolic genes
Peritoneal macrophages of Tyk2-/- and wildtype (wt) mice were compared before and after six hours of LPS treatment. Interferon responsive genes are lower expressed in Tyk2-/- macrophages at the basal level, metabolic genes higher before, but even more after LPS treatment. cDNA from macrophages from ...
ORGANISM(S): Mus musculus 
2010-04-01 | E-GEOD-19733 | biostudies-arrayexpress
ProteomicsTic20-like proteins mediate organelle assembly in Alphaproteobacteria
Organelle-specific protein translocation systems are essential for the biogenesis of many organelles in eukaryotes but thought to be absent from prokaryotic organelles like magnetosomes. Here, using evolutionary analyses, we show that magnetosomal MamF-like proteins represent members of the widespre...
ORGANISM(S): Magnetospirillum gryphiswaldense 
2024-11-19 | PXD032959 | Pride
Mart Magnetosomes Organelles Protein translocation Mamj Tic20 Duf4870 Magnetokeleton 
UnknownMidostaurin in daily clinical practice of patients with advanced systemic mastocytosis.
Not available
S-EPMC12512096 | biostudies-literature
Sort   by:  
 Page size