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MetabolomicsRapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019795 | Pride
Mitosis Mitotic exit Proteolysis Cell cycle Apc/c Proteome 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019791 | Pride
Proteomics Mitosis Mitotic exit Proteolysis Cell cycle Apc/c 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019788 | Pride
Dephosphorylation Phospho-proteomics Mitotic exit Cell cycle Mitosis 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019787 | Pride
Dephosphorylation Mitotis Mitotic exit Cell cycle Apc/c 
ProteomicsOrdered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit
APC/C-mediated proteolysis of cyclin B and securin promotes entry into anaphase, inactivating CDK1 and permitting chromosome segregation, respectively. Reduction of CDK1 activity relieves inhibition of the CDK1-opposing phosphatases PP1 and PP2A-B55 leading to dephosphorylation of substrates crucial...
ORGANISM(S): Homo sapiens (Human) 
2020-09-04 | PXD019786 | Pride
Dephosphorylation Mitosis Phospho-proteomics Mitotic exit Cell cycle Pp1 Apcc 
Metabolomics3D DESI mass spectrometry imaging of 51 serial sections from a human liver metastasis
51 serial sections from a single human liver metastasis are made available in this dataset. Four neighbouring sections were placed on a single slide and analysed together. The tissue sections were analysed by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) according to the pr...
2016-04-28 | MTBLS282 | MetaboLights
Metabolomics3D DESI mass spectrometry imaging of 52 serial sections from a human colorectal adenocarcinoma
Fifty-two serial sections from a single human adenocarcinama are made available in this dataset. Four neighbouring sections were placed on a single slide and analysed together. The tissue sections were analysed by desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) according to t...
2017-03-21 | MTBLS415 | MetaboLights
Proteomics3D-Printed Device for Consistent and High-Throughput Peptide Sample Clean-up Using StageTips
Mass spectrometry (MS) is a fundamental technology for the study of proteomics. A core technique for MS analysis is solid-phase extraction (SPE) for the removal of contaminants and sample concentration, and StageTips are one of the most commonly used devices used for SPE in modern proteomics workflo...
ORGANISM(S): Homo sapiens (Human) 
2019-03-21 | PXD009324 | Pride
3d-printed Stagetip 96-well 
ProteomicsGlobal Enrichment of Low-Abundance Peptide Hormones in Plasma for Discovery and Quantitation
We describe a method for global enrichment of active peptide hormones from blood plasma for both new hormone discovery and quantitative analysis. To extend the dynamic range of plasma proteomics, we employed high-resolution size exclusion chromatography to purify the peptide hormones and a powerful ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-16 | PXD011797 | Pride
Human  plasma  intermittent fasting  peptide hormone  insulin  hepcidin  glp-1  igf-1. 
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