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ProteomicsKinase Inhibitor Pulldown Assay (KiP) for Clinical Proteomics (SureQuant)
Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential, but current approaches are inadequate. For breast cancer treatment for example, the identification and quantification of the protein kinase ERBB2 is...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046169 | Pride
Breast cancer Is-prm Surequant Kip 
ProteomicsKinase Inhibitor Pulldown Assay (KiP) for Clinical Proteomics
Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential, but current approaches are inadequate. For breast cancer treatment for example, the identification and quantification of the protein kinase ERBB2 is...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044655 | Pride
Human Breast Cancer Kinase 
ProteomicsProteogenomic characterization of muscle invasive bladder cancer
To explore potential chemoresistance mechanisms and identify therapeutic opportunities in muscle invasive bladder cancer (MIBC), we conducted comprehensive proteogenomic characterization of 46 pre- and 14 post-treatment MIBC tumors incorporating genomics, transcriptomics, proteomics, and phosphoprot...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD060290 | Pride
Tmt Cancer Bladder cancer 
ProteomicsKiP analysis of ER+ Breast Cancer
Endocrine therapies (ET) combined with CDK4/6 inhibition (CDK4/6i) is standard treatment for estrogen receptor-α-positive (ER+) breast cancer, however lethal drug resistance is common. Proteogenomic analyses of 22 ER+ breast cancer patient-derived xenografts (PDXs) demonstrated that PKMYT1, a WEE1 ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-13 | PXD050619 | Pride
Er+ breast cancer Pkmyt1 Endocrine therapy Cdk4/6 
ProteomicsDecoding Post-Translational Modification Patterns to Gain Functional Insights into Pathogenic Missense Variants
Genome sequencing has uncovered numerous pathogenic missense variants; however, their functional consequences remain largely unexplored, limiting our understanding of their precise roles in diseases. These variants may disrupt post-translational modifications (PTMs), which are crucial for cellular s...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD059468 | Pride
Machine learning Ptm 
ProteomicsDAPK3 modulates migration and invasion of triple negative breast cancers
A mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) was applied to analyze 16 patient-derived xenografts (PDXs) leading to the discovery that Death-Associated Protein Kinase 3 (DAPK3) is significantly and specifically overexpressed in triple negative breast cancer (TNBC). Validatio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD049187 | Pride
Luzp1 Emt Breast cancer Cancer Dapk3 Pdx 
ProteomicsNEOPALANA Proteomgenomic analysis
Neoadjuvant palbociclib and anastrozole (NeoPalAna) is a single-arm phase II clinical trial for patients with stage II/III ER+/HER2- breast cancer. Patients recieved Anastrozole for 4weeks followed by palbociclib. On day 15, patients were biopsied and Ki67% was determined. Patients with Ki67 >10% we...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD058250 | Pride
Estrogen receptor Endocrine therapy Breast cancer 
ProteomicsTop Down Histone H4 - SUM159 Butyrate
Proteins physiologically exist and function as ‘proteoforms’ that arise from one gene but acquire additional function by further variation such as post-translational modification (PTM). When multiple PTMs coexist on single protein molecules top down proteomics becomes the only feasible method; howev...
ORGANISM(S): Homo sapiens (Human) 
2019-11-22 | PXD013766 | Pride
Top-down Histone h4 
ProteomicsActin Methionine Methylation HPLC-MS/MS analysis
HPLC-MS/MS analysis of actin peptide with methionine methylation
ORGANISM(S): Homo sapiens (Human) 
2020-06-24 | PXD019203 | Pride
Actin methionine methylation 
GenomicsChIP-seq Accurately Predicts Tissue-Specific Activity of Enhancers
Determining the spatial and temporal activity patterns of enhancers remains a challenge in the functional annotation of the human genome. Here, we performed genome-wide mapping of tissue-specific in vivo binding sites for the enhancer-associated protein p300 and assessed in transgenic mice the util...
ORGANISM(S): Mus musculus 
2009-02-11 | E-GEOD-13845 | biostudies-arrayexpress
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