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TranscriptomicsMonitoring Homology Search during DNA Double-Strand Break Repair in vivo
Homologous recombination (HR) is crucial for genetic exchange, accurate repair of DNA double-strand breaks and pivotal for genome integrity. HR uses homologous sequences for repair, but how homology search, the exploration of the genome for homologous DNA sequences, is conducted in the nucleus remai...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-21 | E-GEOD-44844 | biostudies-arrayexpress
UnknownSustained Correction of a Murine Model of Phenylketonuria following a Single Intravenous Administration of AAVHSC15-PAH.
Not available
S-EPMC7118282 | biostudies-literature
GenomicsCovalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
Based on the hypothesis that, enhancing the local concentration of donor oligos could increase the correction rates, we generated and tested novel CRISPR-Cas9 systems, in which the DNA repair template is covalently conjugated to Cas9 (RNPD system). To validate our results from the HEK293T reporter c...
ORGANISM(S): Mus musculus 
2018-06-04 | E-MTAB-6808 | biostudies-arrayexpress
UnknownLNA blockers for improved amplification selectivity.
Not available
S-EPMC10038989 | biostudies-literature
ProteomicsHuman POT1 Prevents Severe Telomere Damage Instability Induced by Homology Directed DNA Repair
The evolutionarily conserved POT1 protein binds the single stranded G-rich telomeric DNA and has been implicated in telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics discovering that the complete abs...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD016826 | Pride
Telomeres Affinity purification Mass spectrometry Homology-directed dna repair Tandem mass tags 
GenomicsMechanism of homology search expansion during recombinational DNA repair
Mechanism of homology search expansion during recombinational DNA repair
PRJEB76941 | ENA
ProteomicsHyPep: An Open-Source Software for Identification and Discovery of Neuropeptides using Sequence Homology Searching
Neuropeptides are a class of endogenous peptides that have key regulatory roles in biochemical, physiological, and behavioral processes. Mass spectrometry analyses of neuropeptides often rely on protein informatics tools for database searching and peptide identification. As neuropeptide databases ar...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-02-02 | PXD037058 | Pride
Peptidomics Hypep Homology Mass spectrometry Peptide De novo sequencing Fdr Neuropeptide 
GenomicsMechanism of homology search expansion during recombinational DNA repair
Mechanism of homology search expansion during recombinational DNA repair
PRJNA1139728 | ENA
GenomicsSynergic homology directed recombination by PRDM9 meiotic factor
Synergic homology directed recombination by PRDM9 meiotic factor
PRJEB58704 | ENA
GenomicsRAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair
RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair
PRJNA1298870 | ENA
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