Sort   by:  
 Page size 
ProteomicsPIM1 controls GBP1 activity to limit self-damage and guard against pathogen infection
Pathogen virulence factors interfere with various cellular activities, a disruption that can trigger innate immune responses. Interferon-gamma (IFNγ)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense against intracellular pathogens by dire...
ORGANISM(S): Toxoplasma gondii PRU Homo sapiens (Human) 
2023-07-26 | PXD029463 | Pride
Pim1 Gbp1 Guanylate binding proteins 14-3-3 Host-pathogen interaction Bystander cells Cell intrinsic immunity 
UnknownHuman GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death.
Not available
S-EPMC7435695 | biostudies-literature
UnknownHuman GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii.
Not available
S-EPMC4961618 | biostudies-literature
ProteomicsCaspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, consisting of caspase-4 in humans, initiates pyroptosis upon detecting cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. For its activation, caspase-4 binds the hydrophobic, membrane-embedded lipid A moiety of LPS, but how it accesses lipid A remains unk...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD070731 | Pride
Caspase-4 Immunology Lipopolysaccharide sensing Host-pathogen interaction gbp1 Membrane curvature Inflammasomes 
Sort   by:  
 Page size