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ProteomicsPIM1 controls GBP1 activity to limit self-damage and guard against pathogen infection
Pathogen virulence factors interfere with various cellular activities, a disruption that can trigger innate immune responses. Interferon-gamma (IFNγ)-inducible antimicrobial factors, such as the guanylate binding proteins (GBPs), promote cell-intrinsic defense against intracellular pathogens by dire...
ORGANISM(S): Toxoplasma gondii PRU Homo sapiens (Human) 
2023-07-26 | PXD029463 | Pride
Pim1 Gbp1 Guanylate binding proteins 14-3-3 Host-pathogen interaction Bystander cells Cell intrinsic immunity 
ProteomicsCytokine-induced GBP1 release from human ovarian cancer cells
Background: In previous studies we showed that IL-27 shares several effects with IFN-γ in human cancer cells. To identify novel extracellular mediators, potentially involved in epithelial ovarian cancer (EOC) biology, we analyzed the effect of IL-27 or IFN-γ on the secretome of EOC cells in culture....
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016479 | Pride
Guanosyl binding protein 1 Interleukin-27 Microenvironment. Interferon- Secretome Ovarian cancer 
ProteomicsIn vitro kinase assay Pim1/GBP1
High resolution mass spectrometry-based analysis of an in vitro kinase assay to dissect the PIM1 kinase/GBP1 substrate relationship.
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD030010 | Pride
Phospho Kinase assay Human 
ProteomicsGenetically modified ID8 cells to study the role of GBP1 in ovarian cancer
Genetically modified ovarian cancer cells were used to study the role of GBP1. Proteomics-based thermal stability assay (CETSA) was performed on GBP1 knockdown and overexpressing ID8 ovarian cancer cells. Shotgun proteomics was also performed on these cells.
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD040444 | Pride
Ovarian cancer Knockdown Overexpression Cetsa Gbp1 
GenomicsIFN-γ induction of GBP1 drives aberrant macrophage activation in human skin granulomas
IFN-γ induction of GBP1 drives aberrant macrophage activation in human skin granulomas
PRJNA1228071 | ENA
UnknownStructural insights into the activation mechanism of antimicrobial GBP1.
Not available
S-EPMC10897159 | biostudies-literature
ProteomicsTRIM21 innate immune detection of GBP1-positive Toxoplasma gondii is essential for host survival
Interferon gamma (IFN) is the major pro-inflammatory cytokine conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii. Autophagy along with immunity-related GTPases (IRGs), guanylate binding proteins (GBPs) and the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) m...
ORGANISM(S): Mus musculus (Mouse) Toxoplasma gondii ME49 
2018-03-12 | PXD003217 | Pride
Proteomics Toxoplasma gondii Trim21 
TranscriptomicsIFN-γ induction of GBP1 drives aberrant macrophage activation in human skin granulomas
Granuloma annulare (GA) and cutaneous sarcoidosis (cSAR), non-communicable skin conditions, possess an overlapping immunopathology, in which the aberrant activation of macrophages by IFN-γ constitutes a central driver of disease. Nevertheless, our understanding of the molecular events occurring in p...
ORGANISM(S): Homo sapiens 
2026-04-18 | GSE290458 | GEO
UnknownFunction and mechanism of GBP1 in the development and progression of cervical cancer.
Not available
S-EPMC10763113 | biostudies-literature
UnknownCytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells.
Not available
S-EPMC7072386 | biostudies-literature
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