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ProteomicsTranslocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
The hexameric Cdc48 ATPase (p97 or VCP in mammals) cooperates with its cofactor Ufd1/Npl4 to extract polyubiquitinated proteins from membranes or macromolecular complexes for degradation by the proteasome. Here, we clarify how the Cdc48 complex unfolds its substrates and translocates polypeptides wi...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-01-19 | PXD027639 | Pride
Hydrogen deuterium exchange mass spectrometry Npl4 Unfolding Ufd1 Translocation Ubiquitin Vcp Hdx-ms P97 Aaa atpase 
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