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Proteomicshuman LHR-APEX2 time-resolved proximity proteomics
Cellular signaling by membrane G protein-coupled receptors (GPCRs) is orchestrated by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome as it evolves over time and space in response to an agonist can offer a unique window on pleiotropic signaling decoding and functional s...
ORGANISM(S): Homo sapiens (Human) 
2026-03-20 | PXD053246 | Pride
Proteomics Proximity proteomics Apex2 Lhcgr Lhr Interactomics Gpcr Human 
MetabolomicsABHD11/ROLIP maintains the TCA cycle by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
2-oxoglutarate (2-OG) relates mitochondrial metabolism to cell function: conversion of 2-OG to succinyl-CoA by the 2-OG dehydrogenase complex (OGDHc) is rate-limiting for the Tricarboxylic Acid (TCA) cycle, but 2-OG is also required for oxygen sensitive enzymes (2-OG dependent dioxygenases) that hav...
2020-08-10 | MTBLS1875 | MetaboLights
ProteomicsThe translatome of quiescent Plasmodium falciparum gametocytes reveals parasite pyridoxal 5’-phosphate (PLP) biosynthesis is essential for efficient mosquito stage development
The ability of Plasmodium falciparum gametocytes to remain quiescent within the vertebrate host but poised for rapid onward development in the mosquito is an adaptation essential to maximise the onward spread of malaria. In this dormant state, mature infectious stage V gametocytes are largely unaffe...
ORGANISM(S): Plasmodium falciparum 
2026-03-25 | PXD075878 | Pride
Malaria Plasmodium falciparum Translatome 
ProteomicsThe homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell-cell adhesion
Cell-cell communication in multicellular organisms depends on the dynamic and reversible phosphorylation of protein tyrosine residues. The receptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment and are well placed to influence cell signaling. However, t...
ORGANISM(S): Homo sapiens (Human) 
2019-03-29 | PXD013055 | Pride
Phosphorylation  silac 
ProteomicsDT2216 is a specific BCL-XL PROTAC
To validate the specificity of DT2216, we used the stable isotope labeling with amino acids in cell culture (SILAC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to analyze the changes in proteins in WI-38 normal human diploid fibroblasts after DT2216 and DT2216NC tr...
ORGANISM(S): Homo sapiens (Human) 
2019-10-08 | PXD010878 | Pride
Dt2216 bcl-xl protac silac lc-ms/ms 
ProteomicsMulti-Omics Characterization of Colon Mucosa and Submucosa/Wall from Crohn’s Disease Patients
Crohn’s disease (CD) is a subtype of inflammatory bowel disease (IBD) characterized by transmural disease. The concept of transmural healing (TH) has been proposed as an indicator of deep clinical remission of CD and as a predictor of favorable treatment endpoints. Understanding the pathophysiology ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050335 | Pride
Crohn’s disease  transmural healing  colon  mucosa  submucosa  wall  transcriptomics  proteomics  histology  isoform 
ProteomicsComparative cell surface proteomic analysis of the primary human T cell and monocyte responses to type I interferon
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry for viruses. Nonetheless, the effect of IFN on PM ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD022834 | Pride
T cell Leukocytes Cell surface Antiviral restriction Monocyte Quantitative proteomics Interferon type i (ifn) Plasma membrane 
ProteomicsHuman cytomegalovirus protein RL1 degrades the antiviral factor SLFN11 via recruitment of the CRL4 E3 ubiquitin ligase complex
Human cytomegalovirus (HCMV) is an important human pathogen and a paradigm of viral immune evasion, targeting intrinsic, innate and adaptive immunity. We have employed two novel, orthogonal multiplexed tandem mass tag-based proteomic screens to identify host proteins downregulated by viral factors e...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2022-02-22 | PXD026785 | Pride
Human cytomegalovirus  restriction factor  innate immunity  immune evasion  host-pathogen interaction  schlafen 
UnknownAge-associated mitochondrial DNA mutations cause metabolic remodelling that contributes to accelerated intestinal tumorigenesis.
Not available
S-EPMC7116185 | biostudies-literature
UnknownIdentification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Not available
S-EPMC8034380 | biostudies-literature
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