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ProteomicsHuman HRI Autophosphorylation Profile
Heme-regulated inhibitorRegulated Inhibitor (HRI) is one of the four mammalian kinases that phosphorylate eIF2α, facilitating a cellular response to stress through the regulation of mRNA translation. Originally identified as a heme sensor in erythroid progenitor cells, HRI has since emerged as a pot...
ORGANISM(S): Homo sapiens (Human) 
2025-06-18 | PXD064940 | Pride
Autophosphorylation Hri Kinase 
GenomicsSerratia sp. HRI
Serratia sp. HRI Genome sequencing and assembly
PRJNA580358 | ENA
ProteomicsAssociation of heme bound HRI with S-DELE1 promotes structural re-arrangements within the HRI kinase domain
This dataset assesses structural changes occurring in human, heme-bound HRI upon association with S-DELE1. To this end, human HRI and S-DELE1 were expressed EIF2alpha phosphorylation-resistent cells supplemented with hemin. HRI was affinity purified, crosslinked with DSS, and structural changes in H...
ORGANISM(S): Homo sapiens (Human) 
2026-05-07 | PXD063587 | Pride
Hri Heme Dele1 Xl-ms 
ProteomicsAssociation of heme-bound HRI with S-DELE1 promotes HRI auto-phosphorylation
This dataset assesses the effects of S-DELE1 association on the auto-phosphorylation of human, heme-bound HRI. Human HRI and DELE1 were expressed in EIF2alpha-phospho-resistant cells supplemented with hemin. HRI was affinity purified, the elution subjected to denaturing gel electrophoresis, and HRI...
ORGANISM(S): Homo sapiens (Human) 
2026-06-09 | PXD062916 | Pride
GenomicsHRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation
HRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation
PRJNA631789 | ENA
GenomicsDomain-focused CRISPR-screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Domain-focused CRISPR-screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
PRJNA475769 | ENA
TranscriptomicsHRI depletion cooperates with pharmacologic inducers to elevate fetal hemoglobin and reduce sickle cell formation
Increasing fetal hemoglobin (HbF) provides clinical benefit in patients with sickle cell disease (SCD). We recently identified heme-regulated inhibitor (HRI, EIF2AK1) as a novel HbF regulator. Since HRI is an erythroid-specific protein kinase it presents a potential target for pharmacologic interven...
ORGANISM(S): Homo sapiens 
2020-09-21 | GSE150341 | GEO
GenomicsIron and Heme Coordinate Erythropoiesis through HRI-Mediated Regulation of Protein Translation and Gene Expression
Iron and Heme Coordinate Erythropoiesis through HRI-Mediated Regulation of Protein Translation and Gene Expression
PRJNA488955 | ENA
GenomicsHRI activates ATF4 to promote BCL11A transcription and fetal hemoglobin silencing [ChIP-seq]
HRI activates ATF4 to promote BCL11A transcription and fetal hemoglobin silencing [ChIP-seq]
PRJNA602344 | ENA
GenomicsHRI activates ATF4 to promote BCL11A transcription and fetal hemoglobin silencing [Capture-C]
HRI activates ATF4 to promote BCL11A transcription and fetal hemoglobin silencing [Capture-C]
PRJNA602343 | ENA
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