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ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
UnknownAnalyses of Molecular Characteristics and Enzymatic Activities of Ovine HSD17B3.
Not available
S-EPMC8532638 | biostudies-literature
UnknownAblation of the canonical testosterone production pathway via knockout of the steroidogenic enzyme HSD17B3, reveals a novel mechanism of testicular testosterone production.
Not available
S-EPMC7496839 | biostudies-literature
UnknownA Novel Compound Heterozygous Mutation of HSD17B3 Gene Identified in a Patient With 46,XY Difference of Sexual Development.
Not available
S-EPMC9386624 | biostudies-literature
UnknownDisorder of Sex Development Due to 17-Beta-Hydroxysteroid Dehydrogenase Type 3 Deficiency: A Case Report and Review of 70 Different HSD17B3 Mutations Reported in 239 Patients.
Not available
S-EPMC9456484 | biostudies-literature
TranscriptomicsTranscription profiling of human platelets from patients with essential thrombocythemia
Human blood platelets have important, regulatory functions in diverse hemostatic and pathological disorders, including vascular remodeling, inflammation, and wound repair. Microarray analysis was used to study the molecular basis of essential thrombocythemia, a myeloproliferative disorder with quant...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-2006 | biostudies-arrayexpress
UnknownDifferential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer.
Not available
S-EPMC8303483 | biostudies-literature
TranscriptomicsTestosterone exposure during fetal masculinization programming window determines the kidney size in adult mice
To study the role of fetal testosterone exposure in the development of male mouse kidney, we compared fetal kidneys from WT and testosterone deficient Hsd17b3 KO mice at E16.5, after 2 day testosterone propionate or vehicle treatment.
ORGANISM(S): Mus musculus 
2025-10-23 | GSE280108 | GEO
UnknownThe intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad.
Not available
S-EPMC1892221 | biostudies-literature
UnknownWhole exome sequencing and functional characterization increase diagnostic yield in siblings with a 46, XY difference of sexual development (DSD).
Not available
S-EPMC8725205 | biostudies-literature
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