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GenomicsDown-regulation of SRD5A1 induces autophagy and apoptosis in multiple myeloma
Down-regulation of SRD5A1 induces autophagy and apoptosis in multiple myeloma
PRJNA655885 | ENA
TranscriptomicsDown-regulation of SRD5A1 induces autophagy and apoptosis in multiple myeloma
Steroid 5α-reductase type I (SRD5A1) is a validated oncogene in many sex hormone-related cancers, but its role in multiple myeloma (MM) remains unknown. Based on gene expression profiling of sequential MM samples during disease course, we found that high SRD5A1 expression was correlated with progres...
ORGANISM(S): Homo sapiens 
2021-03-03 | GSE155858 | GEO
GenomicsTranscriptome analysis of SRD5A1 knockdown (Dox) and control (KD) in colorectal cancer
Transcriptome analysis of SRD5A1 knockdown (Dox) and control (KD) in colorectal cancer
PRJNA614912 | ENA
TranscriptomicsTranscriptome analysis of SRD5A1 knockdown (Dox) and control (KD) in colorectal cancer
Transcriptome sequencing was used to analyze changes in related signaling pathways and gene expression in colon cancer cells when SRD5A1 was knocked down.
ORGANISM(S): Homo sapiens 
2020-03-25 | GSE147456 | GEO
UnknownTriple coding in human SRD5A1 mRNA.
Not available
S-EPMC11702784 | biostudies-literature
Unknown5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis.
Not available
S-EPMC3269976 | biostudies-literature
UnknownDifferential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer.
Not available
S-EPMC8303483 | biostudies-literature
UnknownCloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur.
Not available
S-EPMC10636143 | biostudies-literature
ProteomicsIdentifying a novel hydroxysteroid dehydrogenase enzyme that is capable of testosterone biosynthesis in the mouse
Androgens, such as testosterone and dihydrotestosterone (DHT), are essential for male sexual development, masculinisation, spermatogenesis, and general lifelong health. Androgens are predominantly synthesised in the testes of mice (~95%) by highly specialised cells known as the Leydig cells. There a...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-12 | PXD050748 | Pride
Androgens Alternate pathway Hsd17b7 Canonical pathway Testosterone Srd5a1 Testosterone biosynthesis Hsd17b3 
TranscriptomicsExpression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes
We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone (GH)-deficient state. Using microarray profiles, comparison between h-hepatocytes from h-GH-treated and untreated mice identified 14 GH-up-regulated and four GH-down-regul...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26224 | biostudies-arrayexpress
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